Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit

H. Masaki, T. Imaizumi, S. Ando, Yoshitaka Hirooka, S. Harada, M. Momohara, M. Nagano, A. Takeshita

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    24 Citations (Scopus)


    Objective: The aim was to produce a model of low output congestive heart failure by rapid pacing in rabbits. Methods: To perform rapid pacing in rabbits, a custom made pacemaker was developed which is light (about 80 g) and can pace at up to 400 beats · min-1 for more than two weeks. A thoracotomy was done and two electrodes were sutured onto the left ventricle. A central venous pressure line was chronically implanted. With the use of this pacemaker, rabbits were paced at 350-400 beats · min-1 for several weeks. Results: Central venous pressure increased from 1.4(SEM 0.2) to 6.4(0.5) mm Hg (p < 0.01, n = 14). After pacing for 16.1(1.6) d, haemodynamic studies were performed under anaesthesia with thiamylal sodium. Left ventricular end diastolic pressure was higher in the paced rabbits (n = 10) than in the control rabbits which underwent sham operation but were not paced (n = 6), at -0.6(0.6) v 19.3(2.0) mm Hg (p < 0.01). Cardiac output [673(56) v 536(45) ml · min-1, p < 0.10] and +dP/dt [1433(97) v 722(51) mm Hg · s-1, p < 0.01] were lower in the paced rabbits (n = 7-8) than in the control rabbits (n = 6). The paced rabbits had more ascites [1.9(1.0) v 45.9(18.9) ml, p < 0.05] and pleural effusion [0.4(0.3) v 12.9(6.7) ml, p < 0.10] than control rabbits. Plasma noradrenaline was higher in the paced rabbits (n = 11) than in the control rabbits (n = 7), at 1.59(0.43) v 0.60(0.05) ng · ml-1 (p < 0.05). The ratio of wet heart weight or lung weight to body weight was higher (p < 0.01) in the paced rabbits than in the control rabbits. Conclusions: Chronic biventricular congestive heart failure can be produced in rabbits by rapid pacing

    Original languageEnglish
    Pages (from-to)828-831
    Number of pages4
    JournalCardiovascular research
    Issue number5
    Publication statusPublished - Jan 1 1993

    All Science Journal Classification (ASJC) codes

    • Physiology
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)


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