Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system

Yuichi Inoue; Seiji Kawamoto; Kiyohiko Seki; Kiichiro Teruya; Katsumi Mochizuki; Masatoshi Kato; Shuichi Hashizume; Kosei Yasumoto; Akira Nagashima; Hisashi Nakahashi; Tatsuo Suzuki; Tadaaki Imai; Kikuo Nomoto; Sanetaka Shirahata

doi:10.1016/0922-338X(96)85150-6

Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system

Yuichi Inoue, Seiji Kawamoto, Kiyohiko Seki, Kiichiro Teruya, Katsumi Mochizuki, Masatoshi Kato, Shuichi Hashizume, Kosei Yasumoto, Akira Nagashima, Hisashi Nakahashi, Tatsuo Suzuki, Tadaaki Imai, Kikuo Nomoto, Sanetaka Shirahata

Systems Biology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The amplified ras oncogene was used to enhance the productivity of BHK-21 cells producing a lung cancer-reactive human recombinant AE6F4 monoclonal antibody. The recombinant antibody (18 mg) was produced by the ras-amplified BHK-21 cells in a one-month high-density culture using the novel hollow fiber bioreactor system Tecnomouse.

Original language	English
Pages (from-to)	466-469
Number of pages	4
Journal	Journal of Fermentation and Bioengineering
Volume	81
Issue number	5
DOIs	https://doi.org/10.1016/0922-338X(96)85150-6
Publication status	Published - 1996

All Science Journal Classification (ASJC) codes

Biotechnology
Applied Microbiology and Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0922-338X(96)85150-6

Cite this

Inoue, Y., Kawamoto, S., Seki, K., Teruya, K., Mochizuki, K., Kato, M., Hashizume, S., Yasumoto, K., Nagashima, A., Nakahashi, H., Suzuki, T., Imai, T., Nomoto, K., & Shirahata, S. (1996). Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system. Journal of Fermentation and Bioengineering, 81(5), 466-469. https://doi.org/10.1016/0922-338X(96)85150-6

Inoue, Y, Kawamoto, S, Seki, K, Teruya, K, Mochizuki, K, Kato, M, Hashizume, S, Yasumoto, K, Nagashima, A, Nakahashi, H, Suzuki, T, Imai, T, Nomoto, K & Shirahata, S 1996, 'Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system', Journal of Fermentation and Bioengineering, vol. 81, no. 5, pp. 466-469. https://doi.org/10.1016/0922-338X(96)85150-6

@article{8b016c4fe4b94ef3aa0f57f24ecc2054,

title = "Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system",

abstract = "The amplified ras oncogene was used to enhance the productivity of BHK-21 cells producing a lung cancer-reactive human recombinant AE6F4 monoclonal antibody. The recombinant antibody (18 mg) was produced by the ras-amplified BHK-21 cells in a one-month high-density culture using the novel hollow fiber bioreactor system Tecnomouse.",

author = "Yuichi Inoue and Seiji Kawamoto and Kiyohiko Seki and Kiichiro Teruya and Katsumi Mochizuki and Masatoshi Kato and Shuichi Hashizume and Kosei Yasumoto and Akira Nagashima and Hisashi Nakahashi and Tatsuo Suzuki and Tadaaki Imai and Kikuo Nomoto and Sanetaka Shirahata",

year = "1996",

doi = "10.1016/0922-338X(96)85150-6",

language = "English",

volume = "81",

pages = "466--469",

journal = "Journal of Fermentation and Bioengineering",

issn = "0922-338X",

publisher = "The Society for Biotechnology, Japan",

number = "5",

}

TY - JOUR

T1 - Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system

AU - Inoue, Yuichi

AU - Kawamoto, Seiji

AU - Seki, Kiyohiko

AU - Teruya, Kiichiro

AU - Mochizuki, Katsumi

AU - Kato, Masatoshi

AU - Hashizume, Shuichi

AU - Yasumoto, Kosei

AU - Nagashima, Akira

AU - Nakahashi, Hisashi

AU - Suzuki, Tatsuo

AU - Imai, Tadaaki

AU - Nomoto, Kikuo

AU - Shirahata, Sanetaka

PY - 1996

Y1 - 1996

N2 - The amplified ras oncogene was used to enhance the productivity of BHK-21 cells producing a lung cancer-reactive human recombinant AE6F4 monoclonal antibody. The recombinant antibody (18 mg) was produced by the ras-amplified BHK-21 cells in a one-month high-density culture using the novel hollow fiber bioreactor system Tecnomouse.

AB - The amplified ras oncogene was used to enhance the productivity of BHK-21 cells producing a lung cancer-reactive human recombinant AE6F4 monoclonal antibody. The recombinant antibody (18 mg) was produced by the ras-amplified BHK-21 cells in a one-month high-density culture using the novel hollow fiber bioreactor system Tecnomouse.

UR - http://www.scopus.com/inward/record.url?scp=8944246326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8944246326&partnerID=8YFLogxK

U2 - 10.1016/0922-338X(96)85150-6

DO - 10.1016/0922-338X(96)85150-6

M3 - Article

AN - SCOPUS:8944246326

SN - 0922-338X

VL - 81

SP - 466

EP - 469

JO - Journal of Fermentation and Bioengineering

JF - Journal of Fermentation and Bioengineering

IS - 5

ER -

Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this