TY - JOUR
T1 - Pro-senescent effect of hydrogen peroxide on cancer cells and its possible application to tumor suppression
AU - Yoshizaki, Kaichi
AU - Fujiki, Tsukasa
AU - Tsunematsu, Takahiro
AU - Yamashita, Makiko
AU - Udono, Miyako
AU - Shirahata, Sanetaka
AU - Katakura, Yoshinori
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science.
PY - 2009
Y1 - 2009
N2 - Mild oxidative stress is known to induce premature senescence, termed stress-induced premature senescence (SIPS), in normal human diploid cells. We investigated to determine whether mild oxidative stress would trigger SIPS in a human tumor cell line, human lung adenocarcinoma A549. The results showed that sublethal concentrations of H2O2 induced SIPS in A549 cells and consequently attenuated, but did not completely eliminate, the tumorigenicity of these cells. We next investigated the reasons for this incomplete impairment of tumorigenicity in A549 cells in SIPS. The results suggested that H2O2-treated A549 cells are composed of a heterogeneous cell population: one is sensitive to H2O2, and the other is resistant or undergoes reversal; the latter reverted to their original tumorigenic form. The molecular mechanisms determining the cellular fate of tumor cells in SIPS should be identified in order to make use of SIPS and oncogene-induced senescence in tumor cells as methods of tumor suppression.
AB - Mild oxidative stress is known to induce premature senescence, termed stress-induced premature senescence (SIPS), in normal human diploid cells. We investigated to determine whether mild oxidative stress would trigger SIPS in a human tumor cell line, human lung adenocarcinoma A549. The results showed that sublethal concentrations of H2O2 induced SIPS in A549 cells and consequently attenuated, but did not completely eliminate, the tumorigenicity of these cells. We next investigated the reasons for this incomplete impairment of tumorigenicity in A549 cells in SIPS. The results suggested that H2O2-treated A549 cells are composed of a heterogeneous cell population: one is sensitive to H2O2, and the other is resistant or undergoes reversal; the latter reverted to their original tumorigenic form. The molecular mechanisms determining the cellular fate of tumor cells in SIPS should be identified in order to make use of SIPS and oncogene-induced senescence in tumor cells as methods of tumor suppression.
UR - http://www.scopus.com/inward/record.url?scp=65249121386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65249121386&partnerID=8YFLogxK
U2 - 10.1271/bbb.80517
DO - 10.1271/bbb.80517
M3 - Article
C2 - 19202296
AN - SCOPUS:65249121386
SN - 0916-8451
VL - 73
SP - 311
EP - 315
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 2
ER -
