Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: Report of a case

Tomohiko Akahoshi, Hidefumi Higashi, Satoru Tsuruta, Kouichiro Tahara, Toshifumi Matsumoto, Hideya Takeuchi, Shoichi Era, Fuminori Fujita, Yoichi Muto

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13 Citations (Scopus)


Primary hepatic neuroendocrine carcinoma is an extremely rare liver tumor. We herein report a case of primary hepatic neuroendocrine carcinoma coexisting with a hemangioma in a 66-year-old man. Ultrasonography, computed tomography, and magnetic resonance imaging showed a tumor (1.5 cm in diameter) coexisting with a hemangioma in the lateral segment of the liver. Liver biopsy showed malignant cells, and several examinations revealed no alternative primary source. We performed a lateral segmentectomy. Microscopically, the tumor cells had round to oval nuclei and eosinophilic cytoplasm, proliferated in thick trabeculae or solid nests, and formed a focal rosette pattern. Mitotic cells were frequently observed. Immunohistochemically, the tumor cells were positive for the endocrine markers chromogranin A, neuron-specific enolase, and neural cell adhesion molecule, but negative for α-fetoprotein and hepatocyte-specific antigen. The patient is still alive after 3 months, without recurrence.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalSurgery today
Issue number2
Publication statusPublished - Feb 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery


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