Primary mucoepidermoid carcinoma of the liver with CRTC1-MAML2 fusion: A case report

Jiro Watanabe, Keita Kai, Ken Tanikawa, Mamoru Hiraki, Naohisa Mizukami, Shinichi Aishima, Takafumi Nakano, Hidetaka Yamamoto

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background: CRTC1-MAML2 fusion is often detected in low- or intermediate-grade salivary mucoepidermoid carcinoma (MEC), and it is associated with a favorable clinical course. Primary MEC of the liver is an extremely rare, aggressive tumor, and no study has investigated CRTC1-MAML2 fusion. Case presentation: A 79-year-old Japanese female presented with an approx. 5-cm hepatic mass lesion. We surgically resected the lesion under the clinical diagnosis of intrahepatic cholangiocarcinoma. The histological and immunohistochemical findings were consistent with high-grade MEC, consisting of squamoid, mucin-producing, and intermediate tumor cells. Our RT-PCR analysis revealed the presence of CRTC1-MAML2 fusion. This fusion gene was further confirmed by direct sequencing. The patient is still alive almost 10 years after the surgery. Conclusion: This is the first case report of primary MEC of the liver with CRTC1-MAML2 fusion, with long survival. The present case has significant implications for the entity of primary MEC of the liver which should be distinguished from adenosquamous carcinoma.

Original languageEnglish
Article number84
JournalDiagnostic Pathology
Issue number1
Publication statusPublished - Jul 27 2019

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology


Dive into the research topics of 'Primary mucoepidermoid carcinoma of the liver with CRTC1-MAML2 fusion: A case report'. Together they form a unique fingerprint.

Cite this