Primary mediastinal non-seminomatous germ cell tumor associated with hemophagocytic syndrome.

Eriko Sada, Motoaki Shiratsuchi, Junnichi Kiyasu, Kensaku Idutsu, Rie Ohtsuka, Eriko Nagasawa, Kennosuke Karube, Ryoichi Takayanagi, Yasunobu Abe

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


A 20-year-old man with a primary non-seminomatous mediastinal germ cell tumor (yolk sac tumor and immature teratoma) developed hemophagocytic syndrome (HPS) three months after surgical resection. Around the same time, the patient was found to have bone metastases of the germ cell tumor. No other hereditary or acquired diseases related to HPS were found. The thrombocytopenia was refractory to corticosteroid therapy but improved after chemotherapy performed for germ cell tumor progression. Only three cases of germ cell tumor associated with reactive hemophagocytosis have been previously reported. Successful treatment of the present case by chemotherapy for HPS suggests a close relationship between this rare complication and germ cell tumor.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalJournal of clinical and experimental hematopathology : JCEH
Issue number2
Publication statusPublished - Nov 2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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