TY - JOUR
T1 - Prevention of progeny formation in Drosophila melanogaster by 1-arylimidazole-2(3H)-thiones
AU - Hirashima, Akinori
AU - Matsushita, Manabu
AU - Ohta, Hiroto
AU - Nakazono, Kentaro
AU - Kuwano, Eiichi
AU - Eto, Morifusa
N1 - Funding Information:
We thank Dr. N. Inomata (Department of Sciences of Kyushu University) for helping to establish fly assay. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan.
PY - 2006/5
Y1 - 2006/5
N2 - Effects of 1-arylimidazole-2(3H)-thiones (AITs) and 1-(substituted benzyl)imidazole-2(3H)-thiones (BITs) were tested on progeny formation in Drosophila melanogaster. Some AITs showed inhibitory activities at laying eggs and delayed eclosion by 1 day. The inhibitory activity was nullified by adding octopamine (OA) or noradrenaline (NA) to the medium for progeny formation in D. melanogaster. The effect of AIT on the contents of OA and NA was analyzed in adults of D. melanogaster by high-performance liquid chromatography with electrochemical detection. Flies fed with AIT decreased OA and NA levels and increased TA content. Taken together, the inhibitory activity of AIT could be due to inhibition of tyramine β-hydroxylase and dopamine β-hydroxylase.
AB - Effects of 1-arylimidazole-2(3H)-thiones (AITs) and 1-(substituted benzyl)imidazole-2(3H)-thiones (BITs) were tested on progeny formation in Drosophila melanogaster. Some AITs showed inhibitory activities at laying eggs and delayed eclosion by 1 day. The inhibitory activity was nullified by adding octopamine (OA) or noradrenaline (NA) to the medium for progeny formation in D. melanogaster. The effect of AIT on the contents of OA and NA was analyzed in adults of D. melanogaster by high-performance liquid chromatography with electrochemical detection. Flies fed with AIT decreased OA and NA levels and increased TA content. Taken together, the inhibitory activity of AIT could be due to inhibition of tyramine β-hydroxylase and dopamine β-hydroxylase.
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U2 - 10.1016/j.pestbp.2005.09.005
DO - 10.1016/j.pestbp.2005.09.005
M3 - Article
AN - SCOPUS:33646018587
SN - 0048-3575
VL - 85
SP - 15
EP - 20
JO - Pesticide Biochemistry and Physiology
JF - Pesticide Biochemistry and Physiology
IS - 1
ER -