Prevention of progeny formation in Drosophila melanogaster by 1-arylimidazole-2(3H)-thiones

Akinori Hirashima, Manabu Matsushita, Hiroto Ohta, Kentaro Nakazono, Eiichi Kuwano, Morifusa Eto

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5 Citations (Scopus)


Effects of 1-arylimidazole-2(3H)-thiones (AITs) and 1-(substituted benzyl)imidazole-2(3H)-thiones (BITs) were tested on progeny formation in Drosophila melanogaster. Some AITs showed inhibitory activities at laying eggs and delayed eclosion by 1 day. The inhibitory activity was nullified by adding octopamine (OA) or noradrenaline (NA) to the medium for progeny formation in D. melanogaster. The effect of AIT on the contents of OA and NA was analyzed in adults of D. melanogaster by high-performance liquid chromatography with electrochemical detection. Flies fed with AIT decreased OA and NA levels and increased TA content. Taken together, the inhibitory activity of AIT could be due to inhibition of tyramine β-hydroxylase and dopamine β-hydroxylase.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalPesticide Biochemistry and Physiology
Issue number1
Publication statusPublished - May 2006

All Science Journal Classification (ASJC) codes

  • Agronomy and Crop Science
  • Health, Toxicology and Mutagenesis


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