Preparation of porous organically-modified silicate hybrids cell culture matrix

K. Tsuru, S. Hayakawa, Y. Shirosaki, T. Okayama, K. Kataoka, N. H. Huh, A. Osaka

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Porous & rubbery organic-inorganic hybrids were synthesized from tetraethoxysilane (TEOS) and polydimethylsiloxane (PDMS) through a sol-gel route using sieved sucrose granules as a porogen. The porous hybrids with a high content of PDMS behaved like polymer sponge. The porosity was over 90% irrespective of the hybrid composition and the pore diameter ranged from 100 to 500 μm. In the three-dimensional cell culture, mammalian cells were well cultured in the porous hybrids. The present results indicate that the hybrids may be a promising scaffold for developing such functional culture methods.

Original languageEnglish
Pages (from-to)1177-1180
Number of pages4
JournalKey Engineering Materials
Volume330-332 II
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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