Preparation of organotitanium molecular layers for biomedical applications

Tomohiko Yoshioka, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We prepared an organotitanium molecular layer on stainless-steel (SUS316L) substrates, and evaluated its blood compatibility in terms of blood-clotting time and fibrinogen adsorption properties. Titanium methacrylate triisopropoxide (TMT) was used as the organotitanium molecule. The surface was characterized by contact angle measurement toward distilled water and Fourier transform infrared spectroscopy using a reflection absorption method (FT-IRRAS). The obtained organotitanium molecular layer had little effects on the blood-clotting times such as active partial thromboplastin time (PTT) and prothrombin time (PT). Bovine fibrinogen adsorption on the layer was examined from the absorbance of amide I peak in FT-IRRAS spectra. The organotitanium molecular layer reduced the amount of adsorbed fibrinogen compared with stainless-steel.

Original languageEnglish
Pages (from-to)901-905
Number of pages5
JournalMaterials Science and Engineering C
Issue number6-8 SPEC. ISS.
Publication statusPublished - Dec 1 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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