Preparation and characterization of novel cage-type cyclophanes having three or four bridging dipeptide segments

Novel cage-type cyclophanes constructed with two rigid macrocyclic skeletons, triaza[3.3.3]paracyclophanes or tetraaza-[3.3.3.3]paracyclophanes, and three or four dipeptide moieties, α-L-aspartyl-L-aspartyl residues, were prepared. The guest-binding behavior of the cage-type hosts toward fluorescent guests, such as 8-anilinonaphthalene-1-sulfonate and 6-p-toluidinonaphthalene-2-sulfonate, was examined in comparison with that demonstrated by non-cage hosts toward the identical guests.