Preparation and characterization of macroporous carbonate-substituted hydroxyapatite scaffold

Yoong Lee; Yeong Min Hahm; Dong Hyun Lee; Shigeki Matsuya; Masaharu Nakagawa; Kunio Ishikawa

doi:10.1021/ie071474a

Preparation and characterization of macroporous carbonate-substituted hydroxyapatite scaffold

Yoong Lee, Yeong Min Hahm, Dong Hyun Lee, Shigeki Matsuya, Masaharu Nakagawa, Kunio Ishikawa

Oral Rehabilitation

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Abstract

Human bone mineral is different in composition from stoichiometric hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂) in that it contains additional ions, of which CO₃^2- is the most abundant species. Two macroporous carbonate-substituted hydroxyapatite (CHA) scaffolds were prepared by treating a macroporous CaCO₃ column (porosity, 88%; pore and hole size, 160 and 71 μm), prepared in this study, hydrothermally at 120°C in 1 M phosphate solutions of (NH₄) ₂HPO₄ and K₂HPO₄. Especially, it was found that the CaCO₃ was transformed into CHA after hydrothermal treatment (HT) for 24 h irrespective of the type of phosphate solution. Under HT for 24 h, the crystallite size and crystal shape of CHA prepared in K ₂HPO₄ solution (KCHA) and those of CHA prepared in (NH₄)₂HPO₄ (NH₄CHA) were quite different from each other. Moreover, NH₄CHA contained 2.09 wt % A-type CO₃^2- out of 6.05 wt % CO₃^2-, but KCHA contained a small amount of A-type CO₃^2- (0.08 wt % out of 8.24 wt % CO₃^2-). The chemical formulas were Ca_9.23(NH₄)_0.12(PO₄) _5.36(CO₃)_0.64(OH)_0.54(CO ₃)_0.34 for NH₄CHA and Ca_8.18K _0.5(PO₄)_4.72(CO₃) _1.28(OH)_0.1(CO₃)_0.02 for KCHA. Therefore, the properties, such as carbonate type and content, and crystal shape, of CHA are significantly affected by the type of phosphate solution.

Original language	English
Pages (from-to)	2618-2622
Number of pages	5
Journal	Industrial and Engineering Chemistry Research
Volume	47
Issue number	8
DOIs	https://doi.org/10.1021/ie071474a
Publication status	Published - Apr 16 2008

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)
Industrial and Manufacturing Engineering

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10.1021/ie071474a

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@article{5e812d5f61d044bd86246458609e4b91,

title = "Preparation and characterization of macroporous carbonate-substituted hydroxyapatite scaffold",

abstract = "Human bone mineral is different in composition from stoichiometric hydroxyapatite (Ca10(PO4)6(OH)2) in that it contains additional ions, of which CO32- is the most abundant species. Two macroporous carbonate-substituted hydroxyapatite (CHA) scaffolds were prepared by treating a macroporous CaCO3 column (porosity, 88%; pore and hole size, 160 and 71 μm), prepared in this study, hydrothermally at 120°C in 1 M phosphate solutions of (NH4) 2HPO4 and K2HPO4. Especially, it was found that the CaCO3 was transformed into CHA after hydrothermal treatment (HT) for 24 h irrespective of the type of phosphate solution. Under HT for 24 h, the crystallite size and crystal shape of CHA prepared in K 2HPO4 solution (KCHA) and those of CHA prepared in (NH4)2HPO4 (NH4CHA) were quite different from each other. Moreover, NH4CHA contained 2.09 wt % A-type CO32- out of 6.05 wt % CO32-, but KCHA contained a small amount of A-type CO32- (0.08 wt % out of 8.24 wt % CO32-). The chemical formulas were Ca9.23(NH4)0.12(PO4) 5.36(CO3)0.64(OH)0.54(CO 3)0.34 for NH4CHA and Ca8.18K 0.5(PO4)4.72(CO3) 1.28(OH)0.1(CO3)0.02 for KCHA. Therefore, the properties, such as carbonate type and content, and crystal shape, of CHA are significantly affected by the type of phosphate solution.",

author = "Yoong Lee and Hahm, {Yeong Min} and Lee, {Dong Hyun} and Shigeki Matsuya and Masaharu Nakagawa and Kunio Ishikawa",

year = "2008",

month = apr,

day = "16",

doi = "10.1021/ie071474a",

language = "English",

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journal = "Industrial and Engineering Chemistry Research",

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T1 - Preparation and characterization of macroporous carbonate-substituted hydroxyapatite scaffold

AU - Lee, Yoong

AU - Hahm, Yeong Min

AU - Lee, Dong Hyun

AU - Matsuya, Shigeki

AU - Nakagawa, Masaharu

AU - Ishikawa, Kunio

PY - 2008/4/16

Y1 - 2008/4/16

N2 - Human bone mineral is different in composition from stoichiometric hydroxyapatite (Ca10(PO4)6(OH)2) in that it contains additional ions, of which CO32- is the most abundant species. Two macroporous carbonate-substituted hydroxyapatite (CHA) scaffolds were prepared by treating a macroporous CaCO3 column (porosity, 88%; pore and hole size, 160 and 71 μm), prepared in this study, hydrothermally at 120°C in 1 M phosphate solutions of (NH4) 2HPO4 and K2HPO4. Especially, it was found that the CaCO3 was transformed into CHA after hydrothermal treatment (HT) for 24 h irrespective of the type of phosphate solution. Under HT for 24 h, the crystallite size and crystal shape of CHA prepared in K 2HPO4 solution (KCHA) and those of CHA prepared in (NH4)2HPO4 (NH4CHA) were quite different from each other. Moreover, NH4CHA contained 2.09 wt % A-type CO32- out of 6.05 wt % CO32-, but KCHA contained a small amount of A-type CO32- (0.08 wt % out of 8.24 wt % CO32-). The chemical formulas were Ca9.23(NH4)0.12(PO4) 5.36(CO3)0.64(OH)0.54(CO 3)0.34 for NH4CHA and Ca8.18K 0.5(PO4)4.72(CO3) 1.28(OH)0.1(CO3)0.02 for KCHA. Therefore, the properties, such as carbonate type and content, and crystal shape, of CHA are significantly affected by the type of phosphate solution.

AB - Human bone mineral is different in composition from stoichiometric hydroxyapatite (Ca10(PO4)6(OH)2) in that it contains additional ions, of which CO32- is the most abundant species. Two macroporous carbonate-substituted hydroxyapatite (CHA) scaffolds were prepared by treating a macroporous CaCO3 column (porosity, 88%; pore and hole size, 160 and 71 μm), prepared in this study, hydrothermally at 120°C in 1 M phosphate solutions of (NH4) 2HPO4 and K2HPO4. Especially, it was found that the CaCO3 was transformed into CHA after hydrothermal treatment (HT) for 24 h irrespective of the type of phosphate solution. Under HT for 24 h, the crystallite size and crystal shape of CHA prepared in K 2HPO4 solution (KCHA) and those of CHA prepared in (NH4)2HPO4 (NH4CHA) were quite different from each other. Moreover, NH4CHA contained 2.09 wt % A-type CO32- out of 6.05 wt % CO32-, but KCHA contained a small amount of A-type CO32- (0.08 wt % out of 8.24 wt % CO32-). The chemical formulas were Ca9.23(NH4)0.12(PO4) 5.36(CO3)0.64(OH)0.54(CO 3)0.34 for NH4CHA and Ca8.18K 0.5(PO4)4.72(CO3) 1.28(OH)0.1(CO3)0.02 for KCHA. Therefore, the properties, such as carbonate type and content, and crystal shape, of CHA are significantly affected by the type of phosphate solution.

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DO - 10.1021/ie071474a

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AN - SCOPUS:43449096638

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EP - 2622

JO - Industrial and Engineering Chemistry Research

JF - Industrial and Engineering Chemistry Research

IS - 8

ER -

Preparation and characterization of macroporous carbonate-substituted hydroxyapatite scaffold

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