TY - JOUR
T1 - Preoperative transcatheter arterial chemoembolization reduces long-term survival rate after hepatic resection for resectable hepatocellular carcinoma
AU - Sasaki, A.
AU - Iwashita, Y.
AU - Shibata, K.
AU - Ohta, M.
AU - Kitano, S.
AU - Mori, M.
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (No. 16591329), CREST, Japan Science and Technology Agency (JST), and Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research (No. 17109013, 17591411, and 17591413).
PY - 2006/9
Y1 - 2006/9
N2 - Aims: To study the effect of preoperative transcatheter arterial chemoembolization (TACE) on long-term survival after hepatic resection for hepatocellular carcinoma (HCC), we conducted a comparative analysis in 235 HCC patients who underwent hepatic resection with a curative intent. Methods: We compared clinicopathologic background, mortality, and survival rates after hepatic resection between those who underwent preoperative TACE (n = 109) and those who did not (n = 126). Results: One hundred and two patients in the TACE group (93.6%) received TACE only once. The mean interval between TACE and hepatic resection was 33.1 days. Patients in the TACE group were younger than those in the non-TACE group, and liver cirrhosis and non-anatomical hepatic resection were more prevalent in this group. The 5-year overall survival rate after hepatic resection was significantly lower in the TACE group (28.6%) than in the non-TACE group (50.6%), especially in patients without cirrhosis or with stage I or II tumor. There was no difference between the two groups in mortality or disease-free survival after hepatic resection. Multivariate analysis showed preoperative TACE, preoperative aspartate aminotransferase elevation, and microscopic portal invasion to be independent risk factors for a poor outcome after hepatic resection. Conclusions: Preoperative TACE should be avoided for patients with resectable HCC, especially for those without cirrhosis or with an early stage tumor.
AB - Aims: To study the effect of preoperative transcatheter arterial chemoembolization (TACE) on long-term survival after hepatic resection for hepatocellular carcinoma (HCC), we conducted a comparative analysis in 235 HCC patients who underwent hepatic resection with a curative intent. Methods: We compared clinicopathologic background, mortality, and survival rates after hepatic resection between those who underwent preoperative TACE (n = 109) and those who did not (n = 126). Results: One hundred and two patients in the TACE group (93.6%) received TACE only once. The mean interval between TACE and hepatic resection was 33.1 days. Patients in the TACE group were younger than those in the non-TACE group, and liver cirrhosis and non-anatomical hepatic resection were more prevalent in this group. The 5-year overall survival rate after hepatic resection was significantly lower in the TACE group (28.6%) than in the non-TACE group (50.6%), especially in patients without cirrhosis or with stage I or II tumor. There was no difference between the two groups in mortality or disease-free survival after hepatic resection. Multivariate analysis showed preoperative TACE, preoperative aspartate aminotransferase elevation, and microscopic portal invasion to be independent risk factors for a poor outcome after hepatic resection. Conclusions: Preoperative TACE should be avoided for patients with resectable HCC, especially for those without cirrhosis or with an early stage tumor.
UR - http://www.scopus.com/inward/record.url?scp=33747763295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747763295&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2006.04.002
DO - 10.1016/j.ejso.2006.04.002
M3 - Article
C2 - 16797156
AN - SCOPUS:33747763295
SN - 0748-7983
VL - 32
SP - 773
EP - 779
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 7
ER -