Preload sensitivity in cardiac assist devices

Kiyotaka Fukamachi, Akira Shiose, Alex Massiello, David J. Horvath, Leonard A.R. Golding, Sangjin Lee, Randall C. Starling

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)


With implantable cardiac assist devices increasingly proving their effectiveness as therapeutic options for end-stage heart failure, it is important for clinicians to understand the unique physiology of device-assisted circulation. Preload sensitivity as it relates to cardiac assist devices is derived from the Frank-Starling relationship between human ventricular filling pressures and ventricular stroke volume. In this review, we stratify the preload sensitivity of 17 implantable cardiac assist devices relative to the native heart and discuss the effect of preload sensitivity on left ventricular volume unloading, levels of cardiac support, and the future development of continuous-flow total artificial heart technology.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalAnnals of Thoracic Surgery
Issue number1
Publication statusPublished - Jan 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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