Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors

Tetsuhide Ito; Masao Tanaka; Hironobu Sasano; Yoshiyuki R. Osamura; Iwao Sasaki; Wataru Kimura; Koji Takano; Takao Obara; Miyuki Ishibashi; Kazuwa Nakao; Ryuichiro Doi; Akira Shimatsu; Toshirou Nishida; Izumi Komoto; Yukio Hirata; Masayuki Imamura; Ken Kawabe; Kazuhiko Nakamura

doi:10.1007/s00535-007-2056-6

Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors

Tetsuhide Ito, Masao Tanaka, Hironobu Sasano, Yoshiyuki R. Osamura, Iwao Sasaki, Wataru Kimura, Koji Takano, Takao Obara, Miyuki Ishibashi, Kazuwa Nakao, Ryuichiro Doi, Akira Shimatsu, Toshirou Nishida, Izumi Komoto, Yukio Hirata, Masayuki Imamura, Ken Kawabe, Kazuhiko Nakamura

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Abstract

Background: We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Methods: Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results: Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions: The incidence of NETsin Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.

Original language	English
Pages (from-to)	497-500
Number of pages	4
Journal	Journal of gastroenterology
Volume	42
Issue number	6
DOIs	https://doi.org/10.1007/s00535-007-2056-6
Publication status	Published - Jun 2007

All Science Journal Classification (ASJC) codes

Gastroenterology

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10.1007/s00535-007-2056-6

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Ito, T., Tanaka, M., Sasano, H., Osamura, Y. R., Sasaki, I., Kimura, W., Takano, K., Obara, T., Ishibashi, M., Nakao, K., Doi, R., Shimatsu, A., Nishida, T., Komoto, I., Hirata, Y., Imamura, M., Kawabe, K., & Nakamura, K. (2007). Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors. Journal of gastroenterology, 42(6), 497-500. https://doi.org/10.1007/s00535-007-2056-6

Ito, T, Tanaka, M, Sasano, H, Osamura, YR, Sasaki, I, Kimura, W, Takano, K, Obara, T, Ishibashi, M, Nakao, K, Doi, R, Shimatsu, A, Nishida, T, Komoto, I, Hirata, Y, Imamura, M, Kawabe, K & Nakamura, K 2007, 'Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors', Journal of gastroenterology, vol. 42, no. 6, pp. 497-500. https://doi.org/10.1007/s00535-007-2056-6

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title = "Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors",

abstract = "Background: We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Methods: Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results: Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions: The incidence of NETsin Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.",

author = "Tetsuhide Ito and Masao Tanaka and Hironobu Sasano and Osamura, {Yoshiyuki R.} and Iwao Sasaki and Wataru Kimura and Koji Takano and Takao Obara and Miyuki Ishibashi and Kazuwa Nakao and Ryuichiro Doi and Akira Shimatsu and Toshirou Nishida and Izumi Komoto and Yukio Hirata and Masayuki Imamura and Ken Kawabe and Kazuhiko Nakamura",

year = "2007",

month = jun,

doi = "10.1007/s00535-007-2056-6",

language = "English",

volume = "42",

pages = "497--500",

journal = "Journal of gastroenterology",

issn = "0944-1174",

publisher = "Springer Japan",

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T1 - Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors

AU - Ito, Tetsuhide

AU - Tanaka, Masao

AU - Sasano, Hironobu

AU - Osamura, Yoshiyuki R.

AU - Sasaki, Iwao

AU - Kimura, Wataru

AU - Takano, Koji

AU - Obara, Takao

AU - Ishibashi, Miyuki

AU - Nakao, Kazuwa

AU - Doi, Ryuichiro

AU - Shimatsu, Akira

AU - Nishida, Toshirou

AU - Komoto, Izumi

AU - Hirata, Yukio

AU - Imamura, Masayuki

AU - Kawabe, Ken

AU - Nakamura, Kazuhiko

PY - 2007/6

Y1 - 2007/6

N2 - Background: We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Methods: Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results: Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions: The incidence of NETsin Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.

AB - Background: We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Methods: Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results: Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions: The incidence of NETsin Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.

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ER -

Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors

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