@article{6b120fa7c865465c957eff700c770e76,
title = "Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression",
abstract = "Genomic DNA from a panel of 41 healthy unrelated Japanese individuals was typed for the presence or absence of 16 KIR genes and pseudogenes. Only eight different KIR genotypes were found. Group A haplotypes outnumbered group B haplotypes in frequency by approximately 3:1, with individuals having two group A haplotypes accounting for 56% of the panel. The frequency of A haplotypes in the Japanese is higher than that observed in other populations. Flow cytometric comparison of KIR expression in 19 panel members showed considerable diversity in NK cell repertoire, which was also seen within the group of individuals having two A haplotypes. This diversity is likely due to allelic polymorphism in expressed genes of the A haplotype. In comparison to other populations, the Japanese appear less heterogeneous in KIR genotype as assessed by gene content.",
author = "Makoto Yawata and Nobuyo Yawata and McQueen, {Karina L.} and Cheng, {Nathalie W.} and Guethlein, {Lisbeth A.} and Raja Rajalingam and Shilling, {Heather G.} and Peter Parham",
note = "Funding Information: Acknowledgements This work was supported by the National Institute of Health (NIH) grants AI-17892 and AI-22039 to P.P. M.Y. was supported by a grant from the Leukemia Research Foundation. K.L.M. was supported by a fellowship program from the Cancer Research Institute. H.G.S. was supported by NIH training grant 5T32 AI-07290. We gratefully thank all volunteers who donated blood samples for this study. We appreciate the cooperation of Drs. Mutsuhiko Minami, Masatoshi Nakazawa, Motohide Ichi-no, Masahiro Yoshinari, and Haruka Hirose of Yokohama City University, Department of Parasitology and Immunology, in the collection of blood samples. We are grateful to Dr. Lewis Lanier for kindly providing antibodies. We thank Dr. Carlos Vilches for contributing helpful suggestions in the analysis of KIR genotypes.",
year = "2002",
doi = "10.1007/s00251-002-0497-x",
language = "English",
volume = "54",
pages = "543--550",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",
number = "8",
}