TY - JOUR
T1 - Predictors of menstrual resumption by patients with anorexia nervosa
AU - Arimura, Chikako
AU - Nozaki, T.
AU - Takakura, S.
AU - Kawai, K.
AU - Takii, M.
AU - Sudo, N.
AU - Kubo, C.
N1 - Funding Information:
This study was supported by Health and Labour Sciences Research Grants for Research on Intractable Diseases from the Health, Labour, and Welfare Ministry of Japan.
PY - 2010/12
Y1 - 2010/12
N2 - OBJECTIVE: To investigate which factors predict the resumption of menstruation by patients with anorexia nervosa (AN). METHODS: Participants were AN patients who, even after weight recovery by inpatient treatment, had prolonged amenorrhea (N=11), AN patients who resumed menstruation after weight recovery (N=9), and age-matched healthy controls (N=12). Anthropometric data and the serum levels of leptin, insulin-like growth factor I (IGF-1), cortisol, luteinizing hormone (LH), estradiol (E2), and other hormones were measured at the beginning of the inpatient treatment and after weight recovery. RESULTS: Of the baseline anthropometric and hormonal factors, logistic regression analysis extracted a high serum cortisol level as a predictor of the inhibition of the resumption of menstruation. After weight recovery, the E 2 and leptin levels were significantly higher for eumenorrheic patients than for amenorrheic patients. CONCLUSION: The baseline serum cortisol level was a predictor of the prolonged inhibition of menstrual recovery.
AB - OBJECTIVE: To investigate which factors predict the resumption of menstruation by patients with anorexia nervosa (AN). METHODS: Participants were AN patients who, even after weight recovery by inpatient treatment, had prolonged amenorrhea (N=11), AN patients who resumed menstruation after weight recovery (N=9), and age-matched healthy controls (N=12). Anthropometric data and the serum levels of leptin, insulin-like growth factor I (IGF-1), cortisol, luteinizing hormone (LH), estradiol (E2), and other hormones were measured at the beginning of the inpatient treatment and after weight recovery. RESULTS: Of the baseline anthropometric and hormonal factors, logistic regression analysis extracted a high serum cortisol level as a predictor of the inhibition of the resumption of menstruation. After weight recovery, the E 2 and leptin levels were significantly higher for eumenorrheic patients than for amenorrheic patients. CONCLUSION: The baseline serum cortisol level was a predictor of the prolonged inhibition of menstrual recovery.
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U2 - 10.3275/7039
DO - 10.3275/7039
M3 - Article
C2 - 20458162
AN - SCOPUS:79953178963
SN - 1124-4909
VL - 15
SP - e226-e233
JO - Eating and Weight Disorders
JF - Eating and Weight Disorders
IS - 4
ER -
