Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings

Ryoji Kobayashi; Hiromasa Yabe; Junichi Hara; Akira Morimoto; Masahiro Tsuchida; Hideo Mugishima; Akira Ohara; Ichiro Tsukimoto; Koji Kato; Hisato Kigasawa; Ken Tabuchi; Tatsutoshi Nakahata; Shoichi Ohga; Seiji Kojima

doi:10.1111/j.1365-2141.2006.06352.x

Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings

Ryoji Kobayashi, Hiromasa Yabe, Junichi Hara, Akira Morimoto, Masahiro Tsuchida, Hideo Mugishima, Akira Ohara, Ichiro Tsukimoto, Koji Kato, Hisato Kigasawa, Ken Tabuchi, Tatsutoshi Nakahata, Shoichi Ohga, Seiji Kojima

Reproductive and Developmental Medicine

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36 Citations (Scopus)

Abstract

The incidence of graft rejection was determined in 66 children with acquired aplastic anaemia (AA) following bone marrow transplantation (BMT) from a related donor. Eleven of 65 evaluable patients experienced either early or late rejection. Multivariate analysis identified previous immunosuppressive therapy with antithymocyte-globulin (ATG) and ciclosporin (CsA) as a risk factor for graft rejection (relative risk: 16.6, P = 0.001). Patients who received ATG and CsA had a significantly lower probability of failure-free survival than those who did not (69.7 ± 6.2% vs. 87.9 ± 8.0%, P = 0.044). These results suggest that BMT should be instituted immediately in children with severe AA who have human leucocyte antigen-identical siblings.

Original language	English
Pages (from-to)	693-696
Number of pages	4
Journal	British Journal of Haematology
Volume	135
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2141.2006.06352.x
Publication status	Published - Dec 2006

All Science Journal Classification (ASJC) codes

Hematology

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Kobayashi, R., Yabe, H., Hara, J., Morimoto, A., Tsuchida, M., Mugishima, H., Ohara, A., Tsukimoto, I., Kato, K., Kigasawa, H., Tabuchi, K., Nakahata, T., Ohga, S., & Kojima, S. (2006). Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings. British Journal of Haematology, 135(5), 693-696. https://doi.org/10.1111/j.1365-2141.2006.06352.x

Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings. / Kobayashi, Ryoji; Yabe, Hiromasa; Hara, Junichi et al.
In: British Journal of Haematology, Vol. 135, No. 5, 12.2006, p. 693-696.

Research output: Contribution to journal › Article › peer-review

Kobayashi, R, Yabe, H, Hara, J, Morimoto, A, Tsuchida, M, Mugishima, H, Ohara, A, Tsukimoto, I, Kato, K, Kigasawa, H, Tabuchi, K, Nakahata, T, Ohga, S & Kojima, S 2006, 'Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings', British Journal of Haematology, vol. 135, no. 5, pp. 693-696. https://doi.org/10.1111/j.1365-2141.2006.06352.x

Kobayashi R, Yabe H, Hara J, Morimoto A, Tsuchida M, Mugishima H et al. Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings. British Journal of Haematology. 2006 Dec;135(5):693-696. doi: 10.1111/j.1365-2141.2006.06352.x

Kobayashi, Ryoji ; Yabe, Hiromasa ; Hara, Junichi et al. / Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings. In: British Journal of Haematology. 2006 ; Vol. 135, No. 5. pp. 693-696.

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abstract = "The incidence of graft rejection was determined in 66 children with acquired aplastic anaemia (AA) following bone marrow transplantation (BMT) from a related donor. Eleven of 65 evaluable patients experienced either early or late rejection. Multivariate analysis identified previous immunosuppressive therapy with antithymocyte-globulin (ATG) and ciclosporin (CsA) as a risk factor for graft rejection (relative risk: 16.6, P = 0.001). Patients who received ATG and CsA had a significantly lower probability of failure-free survival than those who did not (69.7 ± 6.2% vs. 87.9 ± 8.0%, P = 0.044). These results suggest that BMT should be instituted immediately in children with severe AA who have human leucocyte antigen-identical siblings.",

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AU - Kobayashi, Ryoji

AU - Yabe, Hiromasa

AU - Hara, Junichi

AU - Morimoto, Akira

AU - Tsuchida, Masahiro

AU - Mugishima, Hideo

AU - Ohara, Akira

AU - Tsukimoto, Ichiro

AU - Kato, Koji

AU - Kigasawa, Hisato

AU - Tabuchi, Ken

AU - Nakahata, Tatsutoshi

AU - Ohga, Shoichi

AU - Kojima, Seiji

PY - 2006/12

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AB - The incidence of graft rejection was determined in 66 children with acquired aplastic anaemia (AA) following bone marrow transplantation (BMT) from a related donor. Eleven of 65 evaluable patients experienced either early or late rejection. Multivariate analysis identified previous immunosuppressive therapy with antithymocyte-globulin (ATG) and ciclosporin (CsA) as a risk factor for graft rejection (relative risk: 16.6, P = 0.001). Patients who received ATG and CsA had a significantly lower probability of failure-free survival than those who did not (69.7 ± 6.2% vs. 87.9 ± 8.0%, P = 0.044). These results suggest that BMT should be instituted immediately in children with severe AA who have human leucocyte antigen-identical siblings.

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Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings

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