TY - JOUR
T1 - Prader-Willi syndrome with a cleft palate
T2 - A case report
AU - Kubota, Keigo
AU - Arai, Shinsaku
AU - Mitsuyasu, Takeshi
AU - Matsumura, Kaori
AU - Saijo, Hideto
AU - Hoshi, Kazuto
AU - Nakamura, Seiji
N1 - Funding Information:
The authors wish to thank Dr. Kenji Shimizu (Department of Genetics) and Dr. Hiroshi Miyabayashi (Department of Neonatology), Saitama Children's Medical Center, for their support of this work. The abstract of this manuscript was presented at the 55th Congress of Korean Association of Oral & Maxillofacial Surgeons (2014 Busan, BEXCO).
Publisher Copyright:
© 2020 Asian AOMS(+) ASOMP(+) JSOP(+) JSOMS(+) JSOM(+) and JAMI
PY - 2020/5
Y1 - 2020/5
N2 - Prader-Willi syndrome (PWS) is characterized by infantile hypotonia, hypogonadism, hyperphagia, developmental delay and mild mental retardation and characteristic facial features caused by the lack of genes on chromosome 15q11-q13. Frequency of PWS is estimated to be 1/10,000–1/15,000 and cleft lip and/or palate case is rare. Most PWS babies suffer from hypotonia with feeding problems and speech articulation defects, even though they have normal anatomical structure in oral region. We report a case of PWS with cleft palate (CP). Case: We report on a three-month-old male who was referred to our department from pediatrician of our hospital to treat a cleft in the soft palate. He had hypotonia, feeding problems, almond-shaped eyes and bilateral cryptorchidism at birth. The chromosome test was performed and he was diagnosed as PWS. The volume of milk feeding was improved by feeding training with age. However, when he started feeding with solid foods at 12 months old, a nasal emission was observed, so he disliked eating. After palatoplasty performed at 18 months old, a nasal emission was disappeared and food intake was increased markedly. One year after palatoplasty, his swallowing function was progressed and the velopharyngeal function improved to slight insufficiency. Conclusion: In this case, it is possible that palatoplasty had an effect on not only velopharyngeal functions but also his swallowing functions.
AB - Prader-Willi syndrome (PWS) is characterized by infantile hypotonia, hypogonadism, hyperphagia, developmental delay and mild mental retardation and characteristic facial features caused by the lack of genes on chromosome 15q11-q13. Frequency of PWS is estimated to be 1/10,000–1/15,000 and cleft lip and/or palate case is rare. Most PWS babies suffer from hypotonia with feeding problems and speech articulation defects, even though they have normal anatomical structure in oral region. We report a case of PWS with cleft palate (CP). Case: We report on a three-month-old male who was referred to our department from pediatrician of our hospital to treat a cleft in the soft palate. He had hypotonia, feeding problems, almond-shaped eyes and bilateral cryptorchidism at birth. The chromosome test was performed and he was diagnosed as PWS. The volume of milk feeding was improved by feeding training with age. However, when he started feeding with solid foods at 12 months old, a nasal emission was observed, so he disliked eating. After palatoplasty performed at 18 months old, a nasal emission was disappeared and food intake was increased markedly. One year after palatoplasty, his swallowing function was progressed and the velopharyngeal function improved to slight insufficiency. Conclusion: In this case, it is possible that palatoplasty had an effect on not only velopharyngeal functions but also his swallowing functions.
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U2 - 10.1016/j.ajoms.2019.11.006
DO - 10.1016/j.ajoms.2019.11.006
M3 - Article
AN - SCOPUS:85076545001
SN - 2212-5558
VL - 32
SP - 200
EP - 204
JO - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
JF - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
IS - 3
ER -