PPARα contributes to colonic protection in mice with DSS-induced colitis

Yasu Taka Azuma, Kazuhiro Nishiyama, Yukiko Matsuo, Mitsuru Kuwamura, Ai Morioka, Hidemitsu Nakajima, Tadayoshi Takeuchi

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


Inflammatory bowel disease (IBD) is characterized by repeated chronic inflammation of the gastrointestinal tract. We have used the complementary model of colonic inflammation to examine the roles of peroxisome proliferator-activated receptor α (PPARα) in colonic inflammation and thus its possible role in IBD. We characterized an innate immune-mediated model of colitis induced by dextran sulfate sodium (DSS). Mice with DSS-induced colitis were injected with Wy-14643 (2. mg/kg) as a PPARα agonist every day from day 0 to day 5. We show that mice given Wy-14643 were less susceptible to experimental acute colitis induced by DSS, and this decreased susceptibility was correlated with decreased production of IFNγ, IL-1β, IL-6, and TNF-α. Our findings suggest that PPARα has a role in controlling colonic inflammation and mucosal tissue homeostasis.

Original languageEnglish
Pages (from-to)1261-1267
Number of pages7
JournalInternational Immunopharmacology
Issue number10
Publication statusPublished - Oct 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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