Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D2 receptor

Yuji Yonezawa; Toshihide Kuroki; Nobutada Tashiro; Hisao Hondo; Hideyuki Uchimura

doi:10.1016/0014-2999(95)00527-R

Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D₂ receptor

Yuji Yonezawa, Toshihide Kuroki, Nobutada Tashiro, Hisao Hondo, Hideyuki Uchimura

Clinical Psychology Practice

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Local perfusion with phencyclidine (PCP) increased extracellular dopamine levels in the rat striatum in a dose-dependent manner, as measured by in vivo microdialysis. While pretreatment with SCH 23390, a selective dopamine D₁ receptor antagonist, had no significant effect on PCP-induced increases in extracellular dopamine levels, pretreatment with YM-09151-2 (cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide), a selective dopamine D₂ receptor antagonist, markedly potentiated the effect of PCP. These results suggest that the blockade of dopamine D₂ presynaptic autoreceptors strongly potentiates the PCP-induced dopamine release in the striatum.

Original language	English
Pages (from-to)	305-308
Number of pages	4
Journal	European Journal of Pharmacology
Volume	285
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(95)00527-R
Publication status	Published - Oct 24 1995

All Science Journal Classification (ASJC) codes

Pharmacology

Access to Document

10.1016/0014-2999(95)00527-R

Cite this

@article{d9a7e943b7554499b4aa96790ba2dd17,

title = "Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D2 receptor",

abstract = "Local perfusion with phencyclidine (PCP) increased extracellular dopamine levels in the rat striatum in a dose-dependent manner, as measured by in vivo microdialysis. While pretreatment with SCH 23390, a selective dopamine D1 receptor antagonist, had no significant effect on PCP-induced increases in extracellular dopamine levels, pretreatment with YM-09151-2 (cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide), a selective dopamine D2 receptor antagonist, markedly potentiated the effect of PCP. These results suggest that the blockade of dopamine D2 presynaptic autoreceptors strongly potentiates the PCP-induced dopamine release in the striatum.",

author = "Yuji Yonezawa and Toshihide Kuroki and Nobutada Tashiro and Hisao Hondo and Hideyuki Uchimura",

note = "Funding Information: paper. This study was partly supported by a grant from the Pharmacopsychiatry Research Foundation.",

year = "1995",

month = oct,

day = "24",

doi = "10.1016/0014-2999(95)00527-R",

language = "English",

volume = "285",

pages = "305--308",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D2 receptor

AU - Yonezawa, Yuji

AU - Kuroki, Toshihide

AU - Tashiro, Nobutada

AU - Hondo, Hisao

AU - Uchimura, Hideyuki

N1 - Funding Information: paper. This study was partly supported by a grant from the Pharmacopsychiatry Research Foundation.

PY - 1995/10/24

Y1 - 1995/10/24

N2 - Local perfusion with phencyclidine (PCP) increased extracellular dopamine levels in the rat striatum in a dose-dependent manner, as measured by in vivo microdialysis. While pretreatment with SCH 23390, a selective dopamine D1 receptor antagonist, had no significant effect on PCP-induced increases in extracellular dopamine levels, pretreatment with YM-09151-2 (cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide), a selective dopamine D2 receptor antagonist, markedly potentiated the effect of PCP. These results suggest that the blockade of dopamine D2 presynaptic autoreceptors strongly potentiates the PCP-induced dopamine release in the striatum.

AB - Local perfusion with phencyclidine (PCP) increased extracellular dopamine levels in the rat striatum in a dose-dependent manner, as measured by in vivo microdialysis. While pretreatment with SCH 23390, a selective dopamine D1 receptor antagonist, had no significant effect on PCP-induced increases in extracellular dopamine levels, pretreatment with YM-09151-2 (cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide), a selective dopamine D2 receptor antagonist, markedly potentiated the effect of PCP. These results suggest that the blockade of dopamine D2 presynaptic autoreceptors strongly potentiates the PCP-induced dopamine release in the striatum.

UR - http://www.scopus.com/inward/record.url?scp=0028828646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028828646&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(95)00527-R

DO - 10.1016/0014-2999(95)00527-R

M3 - Article

C2 - 8575518

AN - SCOPUS:0028828646

SN - 0014-2999

VL - 285

SP - 305

EP - 308

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D₂ receptor

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this