Potential pathways in the pathogenesis of IgG4-related disease

Masafumi Moriyama; Seiji Nakamura

doi:10.1007/978-4-431-55687-9_3

Potential pathways in the pathogenesis of IgG4-related disease

Masafumi Moriyama, Seiji Nakamura

Maxillofacial Diagnostic & Surgical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

IgG4-related disease (IgG4-RD) is a systemic disease characterized by elevated serum IgG4 and a marked infiltration of IgG4-positive plasma cells into affected organs. Regarding the immunological aspects of this disease, it is well known that IgG4 is induced by T helper type 2 (Th2) cytokines such as interleukin (IL)-4 and IL-13. Thus, IgG4-RD is considered to be a Th2-predominant disease. In addition, innate immune cells have recently received increasing attention with regards to the initiation of IgG4-RD. Exploring the mechanism of innate and acquired immunity in IgG4-RD is a highly promising field of investigation. In this chapter, we focus on the selective localization and functions of individual Th subsets and innate immune cells to clarify the contribution of these cells to the pathogenesis of IgG4-RD.

Original language	English
Title of host publication	IgG4-Related Kidney Disease
Publisher	Springer Japan
Pages	43-54
Number of pages	12
ISBN (Electronic)	9784431556879
ISBN (Print)	9784431556862
DOIs	https://doi.org/10.1007/978-4-431-55687-9_3
Publication status	Published - Jan 1 2016

All Science Journal Classification (ASJC) codes

Medicine(all)
Immunology and Microbiology(all)

Access to Document

10.1007/978-4-431-55687-9_3

Cite this

@inbook{01268737115b45e1ac35012df55eeef9,

title = "Potential pathways in the pathogenesis of IgG4-related disease",

abstract = "IgG4-related disease (IgG4-RD) is a systemic disease characterized by elevated serum IgG4 and a marked infiltration of IgG4-positive plasma cells into affected organs. Regarding the immunological aspects of this disease, it is well known that IgG4 is induced by T helper type 2 (Th2) cytokines such as interleukin (IL)-4 and IL-13. Thus, IgG4-RD is considered to be a Th2-predominant disease. In addition, innate immune cells have recently received increasing attention with regards to the initiation of IgG4-RD. Exploring the mechanism of innate and acquired immunity in IgG4-RD is a highly promising field of investigation. In this chapter, we focus on the selective localization and functions of individual Th subsets and innate immune cells to clarify the contribution of these cells to the pathogenesis of IgG4-RD.",

author = "Masafumi Moriyama and Seiji Nakamura",

note = "Publisher Copyright: {\textcopyright} Springer Japan 2016.",

year = "2016",

month = jan,

day = "1",

doi = "10.1007/978-4-431-55687-9_3",

language = "English",

isbn = "9784431556862",

pages = "43--54",

booktitle = "IgG4-Related Kidney Disease",

publisher = "Springer Japan",

address = "Japan",

}

TY - CHAP

T1 - Potential pathways in the pathogenesis of IgG4-related disease

AU - Moriyama, Masafumi

AU - Nakamura, Seiji

PY - 2016/1/1

Y1 - 2016/1/1

N2 - IgG4-related disease (IgG4-RD) is a systemic disease characterized by elevated serum IgG4 and a marked infiltration of IgG4-positive plasma cells into affected organs. Regarding the immunological aspects of this disease, it is well known that IgG4 is induced by T helper type 2 (Th2) cytokines such as interleukin (IL)-4 and IL-13. Thus, IgG4-RD is considered to be a Th2-predominant disease. In addition, innate immune cells have recently received increasing attention with regards to the initiation of IgG4-RD. Exploring the mechanism of innate and acquired immunity in IgG4-RD is a highly promising field of investigation. In this chapter, we focus on the selective localization and functions of individual Th subsets and innate immune cells to clarify the contribution of these cells to the pathogenesis of IgG4-RD.

AB - IgG4-related disease (IgG4-RD) is a systemic disease characterized by elevated serum IgG4 and a marked infiltration of IgG4-positive plasma cells into affected organs. Regarding the immunological aspects of this disease, it is well known that IgG4 is induced by T helper type 2 (Th2) cytokines such as interleukin (IL)-4 and IL-13. Thus, IgG4-RD is considered to be a Th2-predominant disease. In addition, innate immune cells have recently received increasing attention with regards to the initiation of IgG4-RD. Exploring the mechanism of innate and acquired immunity in IgG4-RD is a highly promising field of investigation. In this chapter, we focus on the selective localization and functions of individual Th subsets and innate immune cells to clarify the contribution of these cells to the pathogenesis of IgG4-RD.

UR - http://www.scopus.com/inward/record.url?scp=85018538867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018538867&partnerID=8YFLogxK

U2 - 10.1007/978-4-431-55687-9_3

DO - 10.1007/978-4-431-55687-9_3

M3 - Chapter

AN - SCOPUS:85018538867

SN - 9784431556862

SP - 43

EP - 54

BT - IgG4-Related Kidney Disease

PB - Springer Japan

ER -

Potential pathways in the pathogenesis of IgG4-related disease

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this