Postoperative radiotherapy in patients with salivary duct carcinoma: Clinical outcomes and prognostic factors

Makoto Shinoto, Yoshiyuki Shioyama, Katsumasa Nakamura, Torahiko Nakashima, Naonobu Kunitake, Yuichiro Higaki, Tomonari Sasaki, Saiji Ohga, Tadamasa Yoshitake, Kayoko Ohnishi, Kaori Asai, Hideki Hirata, Hiroshi Honda

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


This study sought to investigate the clinical outcome and the role of postoperative radiotherapy for patients with salivary duct carcinoma (SDC) who had undergone surgery and postoperative radiotherapy. We performed a retrospective analysis of 25 SDC patients treated between 1998 and 2011 with surgery and postoperative radiotherapy. The median prescribed dose was 60 Gy (range, 49.5-61.4 Gy). The clinical target volume (CTV) was defined as the tumor bed in four patients, the tumor bed and ipsilateral neck in 14 patients, and the tumor bed and bilateral neck in six patients. Local control (LC), disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan-Meier method, and prognostic variables were analyzed with the log-rank test. The 5-year LC, DFS and OS were 67%, 45% and 47%, respectively. Disease recurrence was found in 12 patients: seven as local, fouras regional and eight as distant failure. Perineural and lymphovascular invasion was a significant prognostic factor for LC (P = 0.03). Local failure was common, and the presence of local recurrence significantly affected the OS (P ≤ 0.05). We conclude that surgery and postoperative radiotherapy is expected to decrease the risk of local failure and contribute to good prognoses for patients with SDC. It might be advisable to have the CTV include the cranial nerves involved and the corresponding parts of the skull base in cases of pathologically positive perineural invasion.

Original languageEnglish
Pages (from-to)925-930
Number of pages6
JournalJournal of radiation research
Issue number5
Publication statusPublished - Sept 2013

All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis


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