TY - JOUR
T1 - Postoperative development of sarcopenia is a strong predictor of a poor prognosis in patients with adenocarcinoma of the esophagogastric junction and upper gastric cancer
AU - Kudou, Kensuke
AU - Saeki, Hiroshi
AU - Nakashima, Yuichiro
AU - Sasaki, Shun
AU - Jogo, Tomoko
AU - Hirose, Kosuke
AU - Hu, Qingjiang
AU - Tsuda, Yasuo
AU - Kimura, Koichi
AU - Nakanishi, Ryota
AU - Kubo, Nobuhide
AU - Ando, Koji
AU - Oki, Eiji
AU - Ikeda, Tetsuo
AU - Maehara, Yoshihiko
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/4
Y1 - 2019/4
N2 - Background: There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC). Methods: Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed. Results: The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P = 0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P = 0.0237). Conclusions: Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC.
AB - Background: There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC). Methods: Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed. Results: The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P = 0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P = 0.0237). Conclusions: Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC.
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U2 - 10.1016/j.amjsurg.2018.07.003
DO - 10.1016/j.amjsurg.2018.07.003
M3 - Article
C2 - 30005807
AN - SCOPUS:85049629832
SN - 0002-9610
VL - 217
SP - 757
EP - 763
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 4
ER -
