Postoperative chemotherapy including intraperitoneal and intradermal administration of the streptococcal preparation OK-432 for patients with gastric cancer and peritoneal dissemination: a prospective randomized study

Keizo Sugimachi; Yoshihiko Maehara; Kouhei Akazawa; Yukifumi Kondo; Yasuo Kunii; Masatsugu Kitamura; Hiroyuki Yamaoka; Yutaka Takahashi; Tsuyoshi Kito; Michio Katou; Hiroshi Furukawa; Shigemitsu Takashima

doi:10.1007/BF00686264

Postoperative chemotherapy including intraperitoneal and intradermal administration of the streptococcal preparation OK-432 for patients with gastric cancer and peritoneal dissemination: a prospective randomized study

Keizo Sugimachi, Yoshihiko Maehara, Kouhei Akazawa, Yukifumi Kondo, Yasuo Kunii, Masatsugu Kitamura, Hiroyuki Yamaoka, Yutaka Takahashi, Tsuyoshi Kito, Michio Katou, Hiroshi Furukawa, Shigemitsu Takashima

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Abstract

We studied the effects on survival time of postoperative immuno-chemotherapy, including the streptococcal preparation OK-432, in patients with gastric cancer and synchronous peritoneal dissemination. The patients were prospectively randomized and a valid statistical assessment could be made for 109. Patients randomized to group B received therapy that is widely used in Japan to treat patients with gastric cancer: mitomycin C (MMC) and UFT, a combination of tegafur and uracil in a molar ratio of 1:4, for 1 year. Patients randomized to group A received the same drugs as were given to group B patients plus OK-432 i.p. for 7 days, beginning on postoperative day 0, and OK-432 by intradermal injection for 1 year, at 2-week intervals. There were no differences between the two groups in any known prognostic factor or in the dose of any drug administered except for OK-432. There was no difference in the toxicity rate between the groups. In this negative trial, there was no improvement in survival time with the addition of OK-432 to MMC and UFT for patients with gastric cancer and peritoneal dissemination.

Original language	English
Pages (from-to)	366-370
Number of pages	5
Journal	Cancer chemotherapy and pharmacology
Volume	33
Issue number	5
DOIs	https://doi.org/10.1007/BF00686264
Publication status	Published - Sept 1994

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Oncology
Toxicology
Pharmacology
Cancer Research
Pharmacology (medical)

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Sugimachi, K., Maehara, Y., Akazawa, K., Kondo, Y., Kunii, Y., Kitamura, M., Yamaoka, H., Takahashi, Y., Kito, T., Katou, M., Furukawa, H., & Takashima, S. (1994). Postoperative chemotherapy including intraperitoneal and intradermal administration of the streptococcal preparation OK-432 for patients with gastric cancer and peritoneal dissemination: a prospective randomized study. Cancer chemotherapy and pharmacology, 33(5), 366-370. https://doi.org/10.1007/BF00686264

Postoperative chemotherapy including intraperitoneal and intradermal administration of the streptococcal preparation OK-432 for patients with gastric cancer and peritoneal dissemination: a prospective randomized study. / Sugimachi, Keizo; Maehara, Yoshihiko; Akazawa, Kouhei et al.
In: Cancer chemotherapy and pharmacology, Vol. 33, No. 5, 09.1994, p. 366-370.

Research output: Contribution to journal › Article › peer-review

Sugimachi, K, Maehara, Y, Akazawa, K, Kondo, Y, Kunii, Y, Kitamura, M, Yamaoka, H, Takahashi, Y, Kito, T, Katou, M, Furukawa, H & Takashima, S 1994, 'Postoperative chemotherapy including intraperitoneal and intradermal administration of the streptococcal preparation OK-432 for patients with gastric cancer and peritoneal dissemination: a prospective randomized study', Cancer chemotherapy and pharmacology, vol. 33, no. 5, pp. 366-370. https://doi.org/10.1007/BF00686264

Sugimachi K, Maehara Y, Akazawa K, Kondo Y, Kunii Y, Kitamura M et al. Postoperative chemotherapy including intraperitoneal and intradermal administration of the streptococcal preparation OK-432 for patients with gastric cancer and peritoneal dissemination: a prospective randomized study. Cancer chemotherapy and pharmacology. 1994 Sept;33(5):366-370. doi: 10.1007/BF00686264

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abstract = "We studied the effects on survival time of postoperative immuno-chemotherapy, including the streptococcal preparation OK-432, in patients with gastric cancer and synchronous peritoneal dissemination. The patients were prospectively randomized and a valid statistical assessment could be made for 109. Patients randomized to group B received therapy that is widely used in Japan to treat patients with gastric cancer: mitomycin C (MMC) and UFT, a combination of tegafur and uracil in a molar ratio of 1:4, for 1 year. Patients randomized to group A received the same drugs as were given to group B patients plus OK-432 i.p. for 7 days, beginning on postoperative day 0, and OK-432 by intradermal injection for 1 year, at 2-week intervals. There were no differences between the two groups in any known prognostic factor or in the dose of any drug administered except for OK-432. There was no difference in the toxicity rate between the groups. In this negative trial, there was no improvement in survival time with the addition of OK-432 to MMC and UFT for patients with gastric cancer and peritoneal dissemination.",

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AU - Takahashi, Yutaka

AU - Kito, Tsuyoshi

AU - Katou, Michio

AU - Furukawa, Hiroshi

AU - Takashima, Shigemitsu

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N2 - We studied the effects on survival time of postoperative immuno-chemotherapy, including the streptococcal preparation OK-432, in patients with gastric cancer and synchronous peritoneal dissemination. The patients were prospectively randomized and a valid statistical assessment could be made for 109. Patients randomized to group B received therapy that is widely used in Japan to treat patients with gastric cancer: mitomycin C (MMC) and UFT, a combination of tegafur and uracil in a molar ratio of 1:4, for 1 year. Patients randomized to group A received the same drugs as were given to group B patients plus OK-432 i.p. for 7 days, beginning on postoperative day 0, and OK-432 by intradermal injection for 1 year, at 2-week intervals. There were no differences between the two groups in any known prognostic factor or in the dose of any drug administered except for OK-432. There was no difference in the toxicity rate between the groups. In this negative trial, there was no improvement in survival time with the addition of OK-432 to MMC and UFT for patients with gastric cancer and peritoneal dissemination.

AB - We studied the effects on survival time of postoperative immuno-chemotherapy, including the streptococcal preparation OK-432, in patients with gastric cancer and synchronous peritoneal dissemination. The patients were prospectively randomized and a valid statistical assessment could be made for 109. Patients randomized to group B received therapy that is widely used in Japan to treat patients with gastric cancer: mitomycin C (MMC) and UFT, a combination of tegafur and uracil in a molar ratio of 1:4, for 1 year. Patients randomized to group A received the same drugs as were given to group B patients plus OK-432 i.p. for 7 days, beginning on postoperative day 0, and OK-432 by intradermal injection for 1 year, at 2-week intervals. There were no differences between the two groups in any known prognostic factor or in the dose of any drug administered except for OK-432. There was no difference in the toxicity rate between the groups. In this negative trial, there was no improvement in survival time with the addition of OK-432 to MMC and UFT for patients with gastric cancer and peritoneal dissemination.

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Postoperative chemotherapy including intraperitoneal and intradermal administration of the streptococcal preparation OK-432 for patients with gastric cancer and peritoneal dissemination: a prospective randomized study

Abstract

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