Wnt/β-catenin signaling is an evolutionarily conserved signaling system that controls cell proliferation and fate during embryogenesis and adult homeostasis. Extensive investigation during the past three decades has made clear that the post-translational modification of β-catenin is a main switch that controls Wnt/β- - catenin signaling in all cells; however, given that Wnt/β-catenin signaling has a great variety of functions, the pathway must be controlled by multiple switches to enable strict spatiotemporal regulation. For the past 15 years, our group has studied the phosphorylation and ubiquitination of Tcf/Lef and discovered that these modifi- cations contribute to the fine-tuning of Wnt/β-catenin signaling in Caenorhabditis elegans and zebrafish. This chapter summarizes our understanding of Tcf/Lef modification and its significance in embryonic development and tissue homeostasis, and discusses the utility of non-mouse animal models in cell signaling studies.
|Title of host publication
|Protein Modifications in Pathogenic Dysregulation of Signaling
|Number of pages
|Published - Sept 2 2015
All Science Journal Classification (ASJC) codes
- General Biochemistry,Genetics and Molecular Biology
- General Medicine