Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium

Susumu Minamisawa, Nobuyuki Uemura, Yoji Sato, Utako Yokoyama, Teruhide Yamaguchi, Kazuhide Inoue, Masamichi Nakagome, Yunzhe Bai, Hideaki Hori, Mitsuyuki Shimizu, Seibu Mochizuki, Yoshihiro Ishikawa

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Thyroid hormone-mediated positive cardiotropic effects are differently regulated between the atria and ventricles. This regulation is, at least in part, dependent on sarcoplasmic reticulum (SR) proteins. Sarcolipin, a homologue of phospholamban, has been recently identified as an atrium-specific SR protein. The expression of sarcolipin mRNA was significantly decreased in the atria of mice with hyperthyroidism and in 3,5,3′-triiodo-l-thyronine-treated neonatal rat atrial myocytes. Promoter activity and mRNA stability analyses revealed that thyroid hormone post-transcriptionally downregulated the expression of sarcolipin mRNA. The atrium-specific effect of thyroid hormone may occur in part through the regulation of atrial sarcolipin gene expression.

Original languageEnglish
Pages (from-to)2247-2252
Number of pages6
JournalFEBS Letters
Issue number9
Publication statusPublished - Apr 17 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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