Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa

Tetsuya Ando, Gen Komaki, Tetsuro Naruo, Kenjiro Okabe, Masato Takii, Keisuke Kawai, Fujiko Konjiki, Michiko Takei, Takakazu Oka, Kaori Takeuchi, Akinori Masuda, Norio Ozaki, Hiroyuki Suematsu, Kenzo Denda, Nobuo Kurokawa, Kotarou Itakura, Chikara Yamaguchi, Masaki Kono, Tatsuyo Suzuki, Yoshikatsu NakaiAya Nishizono-Maher, Masanori Koide, Ken Murakami, Kiyohide Nagamine, Yuichiro Tomita, Kazuyoshi Ookuma, Kazumi Tomita, Eita Tonai, Akira Ooshima, Toshio Ishikawa, Yuhei Ichimaru

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Previous investigations have suggested that ghrelin, an endogenous orexigenic peptide, is involved in the pathology of eating disorders. We conducted a study to determine whether any preproghrelin gene polymorphisms are associated with eating disorders. Three hundred thirty-six eating disorder patients, including 131 anorexia nervosa (AN)-restricting types (AN-R), 97 AN-binge eating/purging types (AN-BP) and 108 bulimia nervosa (BN)-purging types (BN-P), and 300 healthy control subjects participated in the study. Genotyping was performed to determine the polymorphisms present, and with this information, linkage disequilibrium (LD) between the markers was analyzed and the distributions of the genotypes, the allele frequencies, and the haplotype frequencies were compared between the groups. The Leu72Met (408 C > A) (rs696217) polymorphism in exon 2 and the 3056 T > C (rs2075356) polymorphism in intron 2 were in LD (D′ = 0.902, r2 = 0.454). Both polymorphisms were significantly associated with BN-P (allele-wise: P = 0.0410, odds ratio (OR) = 1.48; P = 0.0035, OR = 1.63, for Leu72Met and 3056 T > C, respectively). In addition, we observed a significant increase in the frequency of the haplotype Met72-3056C in BN-P patients (P = 0.0059, OR = 1.71). Our findings suggest that the Leu72-Met (408 C > A) and the 3056 T > C polymorphisms of the preproghrelin gene are associated with susceptibility to BN-P.

Original languageEnglish
Pages (from-to)929-934
Number of pages6
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Issue number8
Publication statusPublished - Dec 5 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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