Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese

Takehiro Torisu, Yutaka Takata, Toshihiro Ansai, Takayuki Matsumoto, Kazuo Sonoki, Inho Soh, Shuji Awano, Akihiro Yoshida, Tomoko Hamasaki, Shuntaro Kagiyama, Ikuo Nakamichi, Tomoko Ohsumi, Kuniaki Toyoshima, Tatsuji Nishihara, Mitsuo Iida, Tadamichi Takehara

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects. Methods: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs. Results: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63±3.50 vs. 15.59± 3.47 p = 0.010, CAVIc; 8.59±1.20 vs. 8.27±1.19 p = 0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group. Conclusion: There may be an association between atrophic gastritis and atherosclerosis in middleaged subjects.

Original languageEnglish
Pages (from-to)691-697
Number of pages7
JournalJournal of atherosclerosis and thrombosis
Issue number5
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical


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