TY - JOUR
T1 - Polyunsaturated fatty acids in serum and homocysteine concentrations in Japanese men and women
T2 - A cross-sectional study
AU - Kume, Ayami
AU - Kurotani, Kayo
AU - Sato, Masao
AU - Ejima, Yuko
AU - Pham, Ngoc Minh
AU - Nanri, Akiko
AU - Kuwahara, Keisuke
AU - Mizoue, Tetsuya
N1 - Funding Information:
We thank Tamami Hatano, Yasumi Kimura and Akihiro Tanaka (Kyushu University); Mio Ozawa (Fukuoka Women’s University); Yaeko Nagano (retired nurse); and Akiko Hayashi and Kie Nagao (National Centre for Global Health and Medicine) for their help in data collection. This study was supported by Grant-in-Aid for Scientific Research (C)(18590601) and (B)(21390213) from Japan Society for the Promotion of Science (to Dr Mizoue). The funding body played no role in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.
PY - 2013
Y1 - 2013
N2 - Background: Supplementation studies have suggested a role of n-3 polyunsaturated fatty acids (PUFAs) in homocysteine metabolism, but the evidence is limited and inconsistent among studies that measured blood levels of n-3 and n-6 PUFAs. We examined the association between blood levels of PUFAs and homocysteine in Japanese men and women. Methods. The subjects were 496 employees (290 men and 206 women) of 2 municipal offices in Japan. Fatty acid composition in serum phospholipids and cholesterol ester (CE) was measured using gas-liquid chromatography. Multiple regression was used to calculate means of homocysteine concentrations according to PUFA tertile with adjustment for potential confounders. Results: Serum homocysteine concentration decreased with increasing levels of total n-3 PUFA, eicosapentaenoic acid and docosahexaenoic acid (DHA) in serum phospholipids and CE with adjustment for age, sex and workplace. However, only DHA in serum phospholipids remained statistically significant after additional adjustment for other potential confounders including serum folate (P-trend = 0.04). N-6 PUFAs were not significantly associated with homocysteine concentrations. Conclusions: Higher proportion of DHA in serum phospholipids may be associated with lower homocysteine concentrations in Japanese men and women.
AB - Background: Supplementation studies have suggested a role of n-3 polyunsaturated fatty acids (PUFAs) in homocysteine metabolism, but the evidence is limited and inconsistent among studies that measured blood levels of n-3 and n-6 PUFAs. We examined the association between blood levels of PUFAs and homocysteine in Japanese men and women. Methods. The subjects were 496 employees (290 men and 206 women) of 2 municipal offices in Japan. Fatty acid composition in serum phospholipids and cholesterol ester (CE) was measured using gas-liquid chromatography. Multiple regression was used to calculate means of homocysteine concentrations according to PUFA tertile with adjustment for potential confounders. Results: Serum homocysteine concentration decreased with increasing levels of total n-3 PUFA, eicosapentaenoic acid and docosahexaenoic acid (DHA) in serum phospholipids and CE with adjustment for age, sex and workplace. However, only DHA in serum phospholipids remained statistically significant after additional adjustment for other potential confounders including serum folate (P-trend = 0.04). N-6 PUFAs were not significantly associated with homocysteine concentrations. Conclusions: Higher proportion of DHA in serum phospholipids may be associated with lower homocysteine concentrations in Japanese men and women.
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U2 - 10.1186/1743-7075-10-41
DO - 10.1186/1743-7075-10-41
M3 - Article
C2 - 23758810
AN - SCOPUS:84878743644
SN - 1743-7075
VL - 10
JO - Nutrition and Metabolism
JF - Nutrition and Metabolism
IS - 1
M1 - 41
ER -
