Polysaccharide schizophyllan-based plasm id DNA carrier

T. Nagasaki, T. Satoh, A. Uno, M. Hojo, K. Koumoto, M. Mizu, K. Sakurai, S. Shinkai

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The development of polysaccharide schizophyllan-based plasmid DNA carrier was analyzed. Amine-introduced cationic schizophyllan (SPG) carriers were prepared using ethanolamine, spermidine, spermine, and N,N'-bis(3-aminopropyl)- 1,3-propanediamine. It was found that transfection efficiency was dependent on cation/anion ratios, with carriers having SPG as the backbone showing the highest transfection efficiency with C/A ratios of 10-15. It was observed that transfection efficiency of the 80,000 Da derivative was about eight times greater than that of PEI.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
Publication statusPublished - 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress


OtherTransactions - 7th World Biomaterials Congress

All Science Journal Classification (ASJC) codes

  • General Engineering


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