Polypoid Carcinoma of the Esophagus

Masaki Mori, Koshi Mimori, Noriaki Sadanaga, Masayuki Watanabe, Hiroyuki Kuwano, Keizo Sugimachi

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17 Citations (Scopus)


Polypoid carcinoma of the esophagus is rare and little is known about its clinical and histopathologic features. We reviewed 500 surgical cases of esophageal carcinoma and analyzed 12 polypoid carcinomas. Clinical records were reviewed. Histologic examination was done on an average of 68 sections in each tumor. Immunohistochemical examination for proliferating cell nuclear antigen (PCNA) was done in selected sections. No special findings were seen with respect to age, sex, symptoms, or tumor location. The tumors, however, had several interesting features: 1) the main histologic type was squamous cell carcinoma, but other histologic features such as so–called carcinosarcoma, adenoid cystic carcinoma, and verrucous carcinoma were occasionally seen, 2) bidirectional differentiation to squamous and adcnocarcinomatous components was recognized, 3) intraepithelial spreading of the carcinoma was often present, 4) depth of invasion in the wall was often shallow, and 5) the prognosis was relatively good. The PCNA labeling index was well correlated with lymphatic or blood vessel permeation.

Original languageEnglish
Pages (from-to)1131-1136
Number of pages6
JournalJapanese Journal of Cancer Research
Issue number11
Publication statusPublished - Nov 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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