TY - JOUR
T1 - Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese
AU - Tsuchiya, Yasuo
AU - Kiyohara, Chikako
AU - Sato, Toyoji
AU - Nakamura, Kazutoshi
AU - Kimura, Akira
AU - Yamamoto, Masaharu
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid from the Ministry of Health and Welfare of Japan as part of the Comprehensive 10-year Strategy for Cancer Control, and in part by a Grant-in-Aid for Scientific Research (C) (2004, #16590473) from the Japanese Ministry of Education, Science, Sports and Culture.
PY - 2007/8
Y1 - 2007/8
N2 - Objectives: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted. Design and methods: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls. Results: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% CI: 1.08-17.2), respectively. No significant differences in the genotypic frequencies of CYP1A1 T3801C and GSTM1 polymorphisms were observed between controls and cases in both men and women. Conclusion: These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
AB - Objectives: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted. Design and methods: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls. Results: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% CI: 1.08-17.2), respectively. No significant differences in the genotypic frequencies of CYP1A1 T3801C and GSTM1 polymorphisms were observed between controls and cases in both men and women. Conclusion: These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
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U2 - 10.1016/j.clinbiochem.2007.04.005
DO - 10.1016/j.clinbiochem.2007.04.005
M3 - Article
C2 - 17531965
AN - SCOPUS:34447550353
SN - 0009-9120
VL - 40
SP - 881
EP - 886
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 12
ER -
