TY - JOUR
T1 - Polymorphism of MDR1 Gene in Healthy Japanese Subjects
T2 - A Novel SNP with an Amino Acid Substitution (Glu108Lys)
AU - Honda, Tomohiro
AU - Dan, Yukihiko
AU - Koyabu, Noriko
AU - Ohtani, Hisakazu
AU - Sawada, Yasufumi
AU - Ieiri, Ichiro
AU - Otsubo, Kenji
AU - Higuchi, Shun
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5' -ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.
AB - We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5' -ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.
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U2 - 10.2133/dmpk.17.479
DO - 10.2133/dmpk.17.479
M3 - Article
AN - SCOPUS:0141961080
SN - 1347-4367
VL - 17
SP - 479
EP - 481
JO - Drug metabolism and pharmacokinetics
JF - Drug metabolism and pharmacokinetics
IS - 5
ER -
