Plastin3 is associated with epithelial-mesenchymal transition and poor prognosis in gastric cancer

Junji Kurashige, Takehiro Yokobori, Kosuke Mima, Genta Sawada, Yusuke Takahashi, Hiroki Ueo, Yuki Takano, T. A.E. Matsumura, Ryutaro Uchi, Hidetoshi Eguchi, Tomoya Sudo, Keishi Sugimachi, Masaki Mori, Hideo Baba, Koshi Mimori

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The plastin3 (PLS3) gene, which encodes an actin bundling protein known to inhibit cofilin-mediated depoly-merization of actin fiber, has been previously reported to serve an important role in the epithelial-mesenchymal transition (EMT) in cancer. The aim of the present study was to determine the clinical significance of PLS3 and its role in regulating EMT, as well as in promoting cell invasion and migration in gastric cancer. The expression of plastin3 mRNA was measured in 163 resected gastric cancer specimens, in order to determine the clinicopathological significance. Furthermore, in vitro invasion and migration assays were performed on gastric cancer cells, which revealed that PLS3 expression was suppressed. The high PLS3 expression group had a higher incidence of advanced tumour stage, cancer differentiation, tumour invasion depth and distant metastases compared with the low PLS3 expression group (P<0.05). In addition, the high PLS3 expression group had a significantly poorer prognosis than the low expression group (P=0.012). Multivariate analysis indicated that high PLS3 expression was an independent prognostic factor for survival. The present study also identified that suppression of PLS3 in gastric cancer cells was associated with decreased cell invasion and migration. The findings from the present study indicate that high expression of PLS3 in gastric cancer is independently associated with a poor prognosis, and that PL3 serves an important role in EMT.

Original languageEnglish
Pages (from-to)2393-2399
Number of pages7
JournalOncology Letters
Issue number2
Publication statusPublished - Feb 2019

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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