Plasmalogen mediates integration of adherens junction

Takanori Takahashi, Masanori Honsho, Yuichi Abe, Yukio Fujiki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Ether glycerolipids, plasmalogens are found in various mammalian cells and tissues. However, physiological role of plasmalogens in epithelial cells remains unknown. We herein show that synthesis of ethanolamine-containing plasmalogens, plasmenylethanolamine (PlsEtn), is deficient in MCF7 cells, an epithelial cell line, with severely reduced expression of alkyl-dihydroxyacetonephosphate synthase (ADAPS), the second enzyme in the PlsEtn biosynthesis. Moreover, expression of ADAPS or supplementation of PlsEtn containing C18-alkenyl residue delays the migration of MCF7 cells as compared to that mock-treated MCF7 and C16-alkenyl-PlsEtn-supplemented MCF7 cells. Localization of E-cadherin to cell-cell junctions is highly augmented in cells containing C18-alkenyl-PlsEtn. Together, these results suggest that PlsEtn containing C18-alkenyl residue plays a distinct role in the integrity of E-cadherin-mediated adherens junction.

Original languageEnglish
Pages (from-to)423-432
Number of pages10
JournalJournal of biochemistry
Issue number5
Publication statusPublished - Nov 1 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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