Plasma orexin-A is lower in patients with narcolepsy

S. Higuchi; A. Usui; M. Murasaki; S. Matsushita; N. Nishioka; A. Yoshino; T. Matsui; H. Muraoka; Y. Ishizuka; S. Kanba; T. Sakurai

doi:10.1016/S0304-3940(01)02476-4

Plasma orexin-A is lower in patients with narcolepsy

S. Higuchi, A. Usui, M. Murasaki, S. Matsushita, N. Nishioka, A. Yoshino, T. Matsui, H. Muraoka, Y. Ishizuka, S. Kanba, T. Sakurai

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71 Citations (Scopus)

Abstract

Recently identified hypothalamic peptides called orexins (or hypocretins) have been implicated in the sleep-wake cycle and in sleep disorder narcolepsy. Neuropathological studies have shown that in patients with narcolepsy, global reduction in the expression of orexins occurs due to the loss of orexin neurons in the hypothalamus. Cerebrospinal fluid analysis has confirmed a reduced or undetectable level of orexin-A in most narcolepsy patients. In this study, measurement of plasma orexin showed significantly lower concentrations in patients with narcolepsy than in age- and gender-matched normal controls. These data suggest that low levels of orexin-A in plasma could serve as a biological marker for narcolepsy.

Original language	English
Pages (from-to)	61-64
Number of pages	4
Journal	Neuroscience Letters
Volume	318
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(01)02476-4
Publication status	Published - Jan 25 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1016/S0304-3940(01)02476-4

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title = "Plasma orexin-A is lower in patients with narcolepsy",

abstract = "Recently identified hypothalamic peptides called orexins (or hypocretins) have been implicated in the sleep-wake cycle and in sleep disorder narcolepsy. Neuropathological studies have shown that in patients with narcolepsy, global reduction in the expression of orexins occurs due to the loss of orexin neurons in the hypothalamus. Cerebrospinal fluid analysis has confirmed a reduced or undetectable level of orexin-A in most narcolepsy patients. In this study, measurement of plasma orexin showed significantly lower concentrations in patients with narcolepsy than in age- and gender-matched normal controls. These data suggest that low levels of orexin-A in plasma could serve as a biological marker for narcolepsy.",

author = "S. Higuchi and A. Usui and M. Murasaki and S. Matsushita and N. Nishioka and A. Yoshino and T. Matsui and H. Muraoka and Y. Ishizuka and S. Kanba and T. Sakurai",

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TY - JOUR

T1 - Plasma orexin-A is lower in patients with narcolepsy

AU - Higuchi, S.

AU - Usui, A.

AU - Murasaki, M.

AU - Matsushita, S.

AU - Nishioka, N.

AU - Yoshino, A.

AU - Matsui, T.

AU - Muraoka, H.

AU - Ishizuka, Y.

AU - Kanba, S.

AU - Sakurai, T.

PY - 2002/1/25

Y1 - 2002/1/25

N2 - Recently identified hypothalamic peptides called orexins (or hypocretins) have been implicated in the sleep-wake cycle and in sleep disorder narcolepsy. Neuropathological studies have shown that in patients with narcolepsy, global reduction in the expression of orexins occurs due to the loss of orexin neurons in the hypothalamus. Cerebrospinal fluid analysis has confirmed a reduced or undetectable level of orexin-A in most narcolepsy patients. In this study, measurement of plasma orexin showed significantly lower concentrations in patients with narcolepsy than in age- and gender-matched normal controls. These data suggest that low levels of orexin-A in plasma could serve as a biological marker for narcolepsy.

AB - Recently identified hypothalamic peptides called orexins (or hypocretins) have been implicated in the sleep-wake cycle and in sleep disorder narcolepsy. Neuropathological studies have shown that in patients with narcolepsy, global reduction in the expression of orexins occurs due to the loss of orexin neurons in the hypothalamus. Cerebrospinal fluid analysis has confirmed a reduced or undetectable level of orexin-A in most narcolepsy patients. In this study, measurement of plasma orexin showed significantly lower concentrations in patients with narcolepsy than in age- and gender-matched normal controls. These data suggest that low levels of orexin-A in plasma could serve as a biological marker for narcolepsy.

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Plasma orexin-A is lower in patients with narcolepsy

Abstract

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