Plasma homovanillic acid, plasma anti-D1 and -D2 dopamine-receptor activity, and negative symptoms in chronically medicated schizophrenia

Eiji Suzuki; Shigenobu Kanba; Masashi Nibuya; Hiroki Koshikawa; Toshio Nakai; Gohei Yagi

doi:10.1016/0006-3223(92)90229-S

Plasma homovanillic acid, plasma anti-D₁ and -D₂ dopamine-receptor activity, and negative symptoms in chronically medicated schizophrenia

Eiji Suzuki, Shigenobu Kanba, Masashi Nibuya, Hiroki Koshikawa, Toshio Nakai, Gohei Yagi

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D₁ and anti-D₂ dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D₁, not anti-D₂ activity, thus suggesting that the neuroleptic-induced changes in pHVA concentration may be associated with the blocking of D₁- as well as D₂- receptors. The change of scores on the Scale for the Assessment of Negative Symptoms did not significantly correlated with changes in anti-D₁ or anti-D₂ activity, but did so correlated with the change in pHVA level.

Original language	English
Pages (from-to)	357-364
Number of pages	8
Journal	Biological Psychiatry
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/0006-3223(92)90229-S
Publication status	Published - Feb 15 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biological Psychiatry

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10.1016/0006-3223(92)90229-S

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title = "Plasma homovanillic acid, plasma anti-D1 and -D2 dopamine-receptor activity, and negative symptoms in chronically medicated schizophrenia",

abstract = "We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D1 and anti-D2 dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D1, not anti-D2 activity, thus suggesting that the neuroleptic-induced changes in pHVA concentration may be associated with the blocking of D1- as well as D2- receptors. The change of scores on the Scale for the Assessment of Negative Symptoms did not significantly correlated with changes in anti-D1 or anti-D2 activity, but did so correlated with the change in pHVA level.",

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AU - Suzuki, Eiji

AU - Kanba, Shigenobu

AU - Nibuya, Masashi

AU - Koshikawa, Hiroki

AU - Nakai, Toshio

AU - Yagi, Gohei

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Y1 - 1992/2/15

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AB - We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D1 and anti-D2 dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D1, not anti-D2 activity, thus suggesting that the neuroleptic-induced changes in pHVA concentration may be associated with the blocking of D1- as well as D2- receptors. The change of scores on the Scale for the Assessment of Negative Symptoms did not significantly correlated with changes in anti-D1 or anti-D2 activity, but did so correlated with the change in pHVA level.

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Plasma homovanillic acid, plasma anti-D₁ and -D₂ dopamine-receptor activity, and negative symptoms in chronically medicated schizophrenia

Abstract

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