Plantar fibromatosis accompanied with multiple keloids-Possible pathogenesis of fibromatosis-

Risa Nakaie, Chikage Mitoma, Masakazu Takahara, Hiroshi Uchi, Masutaka Furue

Research output: Contribution to journalArticlepeer-review


A 56-year-old man noticed a tender subcutaneous nodule on the sole of the left foot two months prior to the first visit. The patient had not been diagnosed with diabetes mellitus. Ultrasound on the foot found a heterogeneous hypoechoic nodule with thin hyperechoic septa. On histology, the plantar subcutaneous nodule demonstrated a proliferation of spindle-shaped cells in company with increased collagen bundles. The spindle cells were positive for alpha-smooth muscle actin and muscle-specific actin (HHF-35), leading to the diagnosis of plantar fibromatosis. In addition, the patient had multiple keloids (two on the right thigh and one on the right shoulder). Plantar fibromatosis, also known as Ledderhose disease, is a relatively rare disease in the field of dermatology and shows reactive fibroblastic proliferation in the plantar aponeurosis with collagen overproduction. We discuss a possible pathogenetic relationship between plantar fibromatosis and keloid.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalNishinihon Journal of Dermatology
Issue number4
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Dermatology


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