Pinacidil inhibits the ryanodine‐sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein

Zhiling Xiong; Shunichi Kajioka; Takeshi Sakai; Kenji Kitamura; Hirosi Kuriyama

doi:10.1111/j.1476-5381.1991.tb12252.x

Pinacidil inhibits the ryanodine‐sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein

Zhiling Xiong
, Shunichi Kajioka
, Takeshi Sakai
, Kenji Kitamura
, Hirosi Kuriyama

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Pinacidil, a potassium‐channel opener, inhibited the ryanodine‐sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP‐sensitive K‐channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist. 1991 British Pharmacological Society

Original language	English
Pages (from-to)	788-790
Number of pages	3
Journal	British Journal of Pharmacology
Volume	102
Issue number	4
DOIs	https://doi.org/10.1111/j.1476-5381.1991.tb12252.x
Publication status	Published - Apr 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1111/j.1476-5381.1991.tb12252.x

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title = "Pinacidil inhibits the ryanodine‐sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein",

abstract = "Pinacidil, a potassium‐channel opener, inhibited the ryanodine‐sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP‐sensitive K‐channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist. 1991 British Pharmacological Society",

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author = "Zhiling Xiong and Shunichi Kajioka and Takeshi Sakai and Kenji Kitamura and Hirosi Kuriyama",

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doi = "10.1111/j.1476-5381.1991.tb12252.x",

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AU - Xiong, Zhiling

AU - Kajioka, Shunichi

AU - Sakai, Takeshi

AU - Kitamura, Kenji

AU - Kuriyama, Hirosi

PY - 1991/4

Y1 - 1991/4

N2 - Pinacidil, a potassium‐channel opener, inhibited the ryanodine‐sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP‐sensitive K‐channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist. 1991 British Pharmacological Society

AB - Pinacidil, a potassium‐channel opener, inhibited the ryanodine‐sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP‐sensitive K‐channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist. 1991 British Pharmacological Society

KW - ATP‐sensitive K channel

KW - Ca release

KW - Ca‐dependent K current

KW - K‐channel opener

KW - Pinacidil

KW - glibenclamide

KW - intracellular Ca store sites

KW - oscillatory outward current

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AN - SCOPUS:0025753487

SN - 0007-1188

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JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 4

ER -

Pinacidil inhibits the ryanodine‐sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein

Abstract

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