Phytochelatins inhibit the metal-induced aggregation of α-crystallin

Yasuhisa Hori; Tomoaki Yoshikawa; Naoki Tsuji; Takeshi Bamba; Yoshikazu Aso; Motonori Kudou; Yoshiki Uchida; Masahiro Takagi; Kazuo Harada; Kazumasa Hirata

doi:10.1016/j.jbiosc.2008.09.021

Phytochelatins inhibit the metal-induced aggregation of α-crystallin

Yasuhisa Hori, Tomoaki Yoshikawa, Naoki Tsuji, Takeshi Bamba, Yoshikazu Aso, Motonori Kudou, Yoshiki Uchida, Masahiro Takagi, Kazuo Harada, Kazumasa Hirata

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Phytochelatins (PCs) are heavy-metal-binding peptides found in some eukaryotes. This study investigates the use of plant-derived PCs for the inhibition of metal-induced protein aggregation. The results of this study show that PCs inhibit zinc-induced α-crystallin aggregation, and suggest that PCs might be useful as anti-cataract agents.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	Journal of Bioscience and Bioengineering
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/j.jbiosc.2008.09.021
Publication status	Published - Feb 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1016/j.jbiosc.2008.09.021

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title = "Phytochelatins inhibit the metal-induced aggregation of α-crystallin",

abstract = "Phytochelatins (PCs) are heavy-metal-binding peptides found in some eukaryotes. This study investigates the use of plant-derived PCs for the inhibition of metal-induced protein aggregation. The results of this study show that PCs inhibit zinc-induced α-crystallin aggregation, and suggest that PCs might be useful as anti-cataract agents.",

author = "Yasuhisa Hori and Tomoaki Yoshikawa and Naoki Tsuji and Takeshi Bamba and Yoshikazu Aso and Motonori Kudou and Yoshiki Uchida and Masahiro Takagi and Kazuo Harada and Kazumasa Hirata",

note = "Funding Information: This research was financially supported by a grant (no. 18659031) from the Japanese Ministry of Education, Culture, Sports, Science and Technology.",

year = "2009",

month = feb,

doi = "10.1016/j.jbiosc.2008.09.021",

language = "English",

volume = "107",

pages = "173--176",

journal = "Journal of Bioscience and Bioengineering",

issn = "1389-1723",

publisher = "The Society for Biotechnology, Japan",

number = "2",

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TY - JOUR

T1 - Phytochelatins inhibit the metal-induced aggregation of α-crystallin

AU - Hori, Yasuhisa

AU - Yoshikawa, Tomoaki

AU - Tsuji, Naoki

AU - Bamba, Takeshi

AU - Aso, Yoshikazu

AU - Kudou, Motonori

AU - Uchida, Yoshiki

AU - Takagi, Masahiro

AU - Harada, Kazuo

AU - Hirata, Kazumasa

N1 - Funding Information: This research was financially supported by a grant (no. 18659031) from the Japanese Ministry of Education, Culture, Sports, Science and Technology.

PY - 2009/2

Y1 - 2009/2

N2 - Phytochelatins (PCs) are heavy-metal-binding peptides found in some eukaryotes. This study investigates the use of plant-derived PCs for the inhibition of metal-induced protein aggregation. The results of this study show that PCs inhibit zinc-induced α-crystallin aggregation, and suggest that PCs might be useful as anti-cataract agents.

AB - Phytochelatins (PCs) are heavy-metal-binding peptides found in some eukaryotes. This study investigates the use of plant-derived PCs for the inhibition of metal-induced protein aggregation. The results of this study show that PCs inhibit zinc-induced α-crystallin aggregation, and suggest that PCs might be useful as anti-cataract agents.

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UR - http://www.scopus.com/inward/citedby.url?scp=60949087202&partnerID=8YFLogxK

U2 - 10.1016/j.jbiosc.2008.09.021

DO - 10.1016/j.jbiosc.2008.09.021

M3 - Article

C2 - 19217556

AN - SCOPUS:60949087202

SN - 1389-1723

VL - 107

SP - 173

EP - 176

JO - Journal of Bioscience and Bioengineering

JF - Journal of Bioscience and Bioengineering

IS - 2

ER -

Phytochelatins inhibit the metal-induced aggregation of α-crystallin

Abstract

All Science Journal Classification (ASJC) codes

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