Physiological insights of recent clinical diagnostic and therapeutic technologies for cardiovascular diseases

Kenji Shigemi, Soichiro Fuke, Dai Une, Keita Saku, Shuji Shimizu, Toru Kawada, Toshiaki Shishido, Kenji Sunagawa, Masaru Sugimachi

    Research output: Contribution to journalReview articlepeer-review

    6 Citations (Scopus)


    Diagnostic and therapeutic methods for cardiovascular diseases continue to be developed in the 21st century. Clinicians should consider the physiological characteristics of the cardiovascular system to ensure successful diagnosis and treatment. In this review, we focus on the roles of cardiovascular physiology in recent diagnostic and therapeutic technologies for cardiovascular diseases. In the first section, we discuss how to evaluate and utilize left ventricular arterial coupling in the clinical settings. In the second section, we review unique characteristics of pulmonary circulation in the diagnosis and treatment of pulmonary hypertension. In the third section, we discuss physiological and anatomical factors associated with graft patency after coronary artery bypass grafting. In the last section, we discuss the usefulness of mechanical ventricular unloading after acute myocardial infarction. Clinical development of diagnostic methods and therapies for cardiovascular diseases should be based on physiological insights of the cardiovascular system.

    Original languageEnglish
    Pages (from-to)655-672
    Number of pages18
    JournalJournal of Physiological Sciences
    Issue number6
    Publication statusPublished - Nov 1 2017

    All Science Journal Classification (ASJC) codes

    • Medicine(all)


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