Photochemical generation of C4'-oxidized abasic site containing oligonucleotide and its amine modification reaction.

Kazuteru Usui; Mariko Aso; Yukiko Toguchi; Yoshie Kakihara; Tsuyoshi Goromaru; Hiroshi Suemune

doi:10.1093/nass/nrl084

Photochemical generation of C4'-oxidized abasic site containing oligonucleotide and its amine modification reaction.

Kazuteru Usui, Mariko Aso, Yukiko Toguchi, Yoshie Kakihara, Tsuyoshi Goromaru, Hiroshi Suemune

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Meeting Abstract

Abstract

We studied photochemical generation of oligodeoxynucleotide (ODN) containing C4'-oxidized abasic site (1) from its caged precursor 3. Photoirradiation of 3 at 365 nm followed by amine treatment under neutral conditions afforded the lactam (2) efficiently. Duplexed ODN 3 was converted to 1 faster and more efficiently than single stranded 3, whereas amine treatment of 1 formed from single stranded 3 resulted in slightly faster lactam formation than with duplex.

Original language	English
Pages (from-to)	169-170
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	50
DOIs	https://doi.org/10.1093/nass/nrl084
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1093/nass/nrl084

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title = "Photochemical generation of C4'-oxidized abasic site containing oligonucleotide and its amine modification reaction.",

abstract = "We studied photochemical generation of oligodeoxynucleotide (ODN) containing C4'-oxidized abasic site (1) from its caged precursor 3. Photoirradiation of 3 at 365 nm followed by amine treatment under neutral conditions afforded the lactam (2) efficiently. Duplexed ODN 3 was converted to 1 faster and more efficiently than single stranded 3, whereas amine treatment of 1 formed from single stranded 3 resulted in slightly faster lactam formation than with duplex.",

author = "Kazuteru Usui and Mariko Aso and Yukiko Toguchi and Yoshie Kakihara and Tsuyoshi Goromaru and Hiroshi Suemune",

year = "2006",

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journal = "Nucleic acids symposium series (2004)",

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T1 - Photochemical generation of C4'-oxidized abasic site containing oligonucleotide and its amine modification reaction.

AU - Usui, Kazuteru

AU - Aso, Mariko

AU - Toguchi, Yukiko

AU - Kakihara, Yoshie

AU - Goromaru, Tsuyoshi

AU - Suemune, Hiroshi

PY - 2006

Y1 - 2006

N2 - We studied photochemical generation of oligodeoxynucleotide (ODN) containing C4'-oxidized abasic site (1) from its caged precursor 3. Photoirradiation of 3 at 365 nm followed by amine treatment under neutral conditions afforded the lactam (2) efficiently. Duplexed ODN 3 was converted to 1 faster and more efficiently than single stranded 3, whereas amine treatment of 1 formed from single stranded 3 resulted in slightly faster lactam formation than with duplex.

AB - We studied photochemical generation of oligodeoxynucleotide (ODN) containing C4'-oxidized abasic site (1) from its caged precursor 3. Photoirradiation of 3 at 365 nm followed by amine treatment under neutral conditions afforded the lactam (2) efficiently. Duplexed ODN 3 was converted to 1 faster and more efficiently than single stranded 3, whereas amine treatment of 1 formed from single stranded 3 resulted in slightly faster lactam formation than with duplex.

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DO - 10.1093/nass/nrl084

M3 - Meeting Abstract

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AN - SCOPUS:36048995233

SN - 1746-8272

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EP - 170

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 50

ER -

Photochemical generation of C4'-oxidized abasic site containing oligonucleotide and its amine modification reaction.

Abstract

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