TY - JOUR
T1 - Phenotypic expression of gastrointestinal differentiation markers in colorectal adenocarcinomas with liver metastasis
AU - Yao, Takashi
AU - Takata, Miyuki
AU - Tustsumi, Shuichi
AU - Nishiyama, Ken Ichi
AU - Taguchi, Ken Ichi
AU - Nagai, Eishi
AU - Tsuneyoshi, Masazumi
N1 - Funding Information:
ACKNOWLEDGEMENTS This work was supported in part by Grants-in-Aid for Cancer Research from the Ministry of Education, Science, and Culture, Japan, and the Fukuoka Cancer Society, Fukuoka, Japan.
PY - 2002/12
Y1 - 2002/12
N2 - Aim: The purpose of the present study was to clarify the correlation between phenotypic expression of gastrointestinal differentiation markers and colorectal cancer behaviour, particularly invasion and hepatic metastasis. Methods: Thirty-one cases of advanced colorectal adenocarcinoma (CRC) with liver metastasis were selected. Phenotypic patterns were evaluated immunohistochemically by means of antibodies to CD10, MUC2, and human gastric mucin (HGM). Results: The incidence of MUC2 (45.2%) and HGM (16.1%) expression in CRCs with liver metastasis did not differ from non-metastatic CRCs. In contrast, the incidence of CD10 expression was significantly higher in CRCs with liver metastasis (58.1%) than in control CRCs (21.7%). Phenotypic expression in the liver metastasis carcinomas was similar to that of the primary lesions. Conclusions: The findings suggest that cases of CRC with CD10 expression are at increased risk of liver metastasis. Even if there is no liver metastasis at laparotomy for CRC, careful follow-up is recommended for CRCs with CD10 expression.
AB - Aim: The purpose of the present study was to clarify the correlation between phenotypic expression of gastrointestinal differentiation markers and colorectal cancer behaviour, particularly invasion and hepatic metastasis. Methods: Thirty-one cases of advanced colorectal adenocarcinoma (CRC) with liver metastasis were selected. Phenotypic patterns were evaluated immunohistochemically by means of antibodies to CD10, MUC2, and human gastric mucin (HGM). Results: The incidence of MUC2 (45.2%) and HGM (16.1%) expression in CRCs with liver metastasis did not differ from non-metastatic CRCs. In contrast, the incidence of CD10 expression was significantly higher in CRCs with liver metastasis (58.1%) than in control CRCs (21.7%). Phenotypic expression in the liver metastasis carcinomas was similar to that of the primary lesions. Conclusions: The findings suggest that cases of CRC with CD10 expression are at increased risk of liver metastasis. Even if there is no liver metastasis at laparotomy for CRC, careful follow-up is recommended for CRCs with CD10 expression.
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U2 - 10.1080/0031302021000035965-4
DO - 10.1080/0031302021000035965-4
M3 - Article
C2 - 12555994
AN - SCOPUS:0036915033
SN - 0031-3025
VL - 34
SP - 556
EP - 560
JO - Pathology
JF - Pathology
IS - 6
ER -
