TY - JOUR
T1 - Phase-locked theta activity evoked in patients with severe motor and intellectual disabilities upon hearing own names
AU - Tamura, Kaori
AU - Karube, Chihiro
AU - Mizuba, Takaaki
AU - Matsufuji, Mayumi
AU - Takashima, Sachio
AU - Iramina, Keiji
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (Nos. 23650267 , 25560287 ) and a Grant-in-Aid for Japan Society for the Promotion of Science (JSPS) Fellows (No. 264908 ).
Publisher Copyright:
© 2014 The Japanese Society of Child Neurology.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Background: Severe motor and intellectual disability (SMID) patients cannot express their feelings with language. Understanding what they are thinking about or how they feel is thus difficult. This study focused on brain responses to hearing their own names to clarify the situation in these patients. Methods: We performed and analyzed electroencephalography (EEG) for six patients with SMID and eleven healthy subjects. All subjects were presented with auditory stimuli including calling the subject's own name (SON) and reading words. EEG was analyzed by time-frequency analysis, event-related spectral perturbation (ERSP) to detect EEG power changes caused by EEG amplitude, and inter-trial coherence (ITC) to investigate phase-locked changes. Results: ERSP results from healthy subjects showed significant theta power increases as a specific response to SON. While we could not identify a similar pattern in the responses of patients with SMID, analysis of ITC revealed that theta phase-locked activity increased in response to SON not only in all healthy subjects, but also in four patients. Discussion: These results indicate that theta phase-locked activity in some patients with SMID was strongly associated with SON, as in healthy subjects. Our study suggests the existence of specific neural markers that signal an attentional shift in patients upon hearing SON.
AB - Background: Severe motor and intellectual disability (SMID) patients cannot express their feelings with language. Understanding what they are thinking about or how they feel is thus difficult. This study focused on brain responses to hearing their own names to clarify the situation in these patients. Methods: We performed and analyzed electroencephalography (EEG) for six patients with SMID and eleven healthy subjects. All subjects were presented with auditory stimuli including calling the subject's own name (SON) and reading words. EEG was analyzed by time-frequency analysis, event-related spectral perturbation (ERSP) to detect EEG power changes caused by EEG amplitude, and inter-trial coherence (ITC) to investigate phase-locked changes. Results: ERSP results from healthy subjects showed significant theta power increases as a specific response to SON. While we could not identify a similar pattern in the responses of patients with SMID, analysis of ITC revealed that theta phase-locked activity increased in response to SON not only in all healthy subjects, but also in four patients. Discussion: These results indicate that theta phase-locked activity in some patients with SMID was strongly associated with SON, as in healthy subjects. Our study suggests the existence of specific neural markers that signal an attentional shift in patients upon hearing SON.
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U2 - 10.1016/j.braindev.2014.11.009
DO - 10.1016/j.braindev.2014.11.009
M3 - Article
C2 - 25530126
AN - SCOPUS:84939254895
SN - 0387-7604
VL - 37
SP - 764
EP - 772
JO - Brain and Development
JF - Brain and Development
IS - 8
ER -