Pharmacokinetics Study of Low Dose of Metformin Clinically Used in Japan

Masanori Iwase, Sakae Nohara, Nobuhiro Sasaki, Toshitaka Himeno, Mariko Nishida, Mototaka Yoshinari, Hideyuki Yoshizumi, Naoko Mukai, Yasufumi Doi, Shigeaki Morizono, Tamotsu Asano, Nobutaka Tsutsu, Mitsuo Iida

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1 Citation (Scopus)


We conducted pharmacokinetic studies after oral administration of 250 mg metformin to reexamine its dose-setting in Japan, where the maximum dose is limited to 750 mg daily. T max was 4 hrs in healthy controls(n=6) and diabetic patients(n=5). C max was 0.54±0.15 μg/ml in control and 0.85±0.19 μg/ml in diabetic patients, consistent with data reported in the English literature. In repetitive administration of 500 mg metformin daily for 7 days, serum concentration of metformin reached the steady state on day 3, and the profile of metformin concentration on day 7 fitted well with the concentration curve predicted by that on day 1. No significant differences were seen in T max, C max, or T 1/2 on days 1 and 7. We report the pharmacokinetics of metformin at the dose set in Japan.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalJournal of the Japan Diabetes Society
Issue number3
Publication statusPublished - 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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