Pharmaceuticals and personal care products toxicity to Japanese medaka fish (Oryzias latipes)

Mohamed Nassef, Shuhei Matsumoto, Masanori Seki, Ik Joon Kang, Junya Moroishi, Yohei Shimasaki, Yuji Oshima

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


We evaluated the acute toxicity of some pharmaceuticals and personal care products (PPCPs) to the survival of Japanese medaka (Oryzias latipes). Adult medaka were exposed to different concentrations of triclosan (TCS; 1, 2, 2.4 and 3mg/L), diclofenac (DCF; 9,12,15 and 18mg/L) or carbamazepine (CBMZ; 60, 65, 70, 90 and 100 mg/L) for 96 h in a semi-static water exposure system. In order of decreasing toxicity to medaka, the 96-h LC50 values were TCS, 1.7 mg/L; DCF, 10.1 mg/L; and CBMZ, 61.5 mg/L. We compared the no observed effect concentration (NOEC) determined from this study with the predicted environmental concentrations (PEC) and concluded that TCS and DCF pose potential risks to medaka but the risk from CBMZ is negligible.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalJournal of the Faculty of Agriculture, Kyushu University
Issue number2
Publication statusPublished - Oct 2009

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science


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