TY - JOUR
T1 - PET evaluation of the relationship between D2 receptor binding and glucose metabolism in patients with parkinsonism
AU - Nakagawa, Makoto
AU - Kuwabara, Yasuo
AU - Taniwaki, Takayuki
AU - Sasaki, Masayuki
AU - Koga, Hirofumi
AU - Kaneko, Koichiro
AU - Hayashi, Kazutaka
AU - Kira, Jun Ichi
AU - Honda, Hiroshi
N1 - Funding Information:
The authors thank Dr. Brian Quinn for his editorial assistance, and the technologists in the Division of Nuclear Medicine at Kyushu University Hospital for their technical assistance. This study was partially supported by grants from the Japanese Ministry of Health, Labor and Welfare and from the Japanese Ministry of Education, Culture, Sports, Science and Technology.
PY - 2005/6
Y1 - 2005/6
N2 - Objective: To clarify the relationship between D2 receptor binding and the cerebral metabolic rate for glucose (CMRGlu) in patients with parkinsonism, we simultaneously measured both of these factors, and then compared the results. Methods: The subjects consisted of 24 patients: 9 with Parkinson's disease (PD), 3 with Juvenile Parkinson's disease (JPD), 9 with multiple system atrophy (MSA), and 3 with progressive supranuclear palsy (PSP). The striatal D2 receptor binding was measured by the C-11 raclopride transient equilibrium method. CMRGlu was investigated by the F-18 fluorodeoxyglucose autoradiographic method. Results: The D2 receptor binding in both the caudate nucleus and putamen showed a positive correlation with the CMRGlu in the PD-JPD group, but the two parameters demonstrated no correlation in the MSA-PSP group. The left/right (L/R) ratio of D2 receptor binding in the putamen showed a positive correlation with that of CMRGlu in the MSA-PSP group, while the two demonsrated no correlation in the PD-JPD group. Conclusion: Our PET study showed striatal D2 receptor binding and the CMRGlu to be closely related in patients with parkinsonism, even though the results obtained using the L/R ratios tended to differ substantially from those obtained using absolute values. The reason for this difference is not clear, but this finding may reflect the pathophysiology of these disease entities.
AB - Objective: To clarify the relationship between D2 receptor binding and the cerebral metabolic rate for glucose (CMRGlu) in patients with parkinsonism, we simultaneously measured both of these factors, and then compared the results. Methods: The subjects consisted of 24 patients: 9 with Parkinson's disease (PD), 3 with Juvenile Parkinson's disease (JPD), 9 with multiple system atrophy (MSA), and 3 with progressive supranuclear palsy (PSP). The striatal D2 receptor binding was measured by the C-11 raclopride transient equilibrium method. CMRGlu was investigated by the F-18 fluorodeoxyglucose autoradiographic method. Results: The D2 receptor binding in both the caudate nucleus and putamen showed a positive correlation with the CMRGlu in the PD-JPD group, but the two parameters demonstrated no correlation in the MSA-PSP group. The left/right (L/R) ratio of D2 receptor binding in the putamen showed a positive correlation with that of CMRGlu in the MSA-PSP group, while the two demonsrated no correlation in the PD-JPD group. Conclusion: Our PET study showed striatal D2 receptor binding and the CMRGlu to be closely related in patients with parkinsonism, even though the results obtained using the L/R ratios tended to differ substantially from those obtained using absolute values. The reason for this difference is not clear, but this finding may reflect the pathophysiology of these disease entities.
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U2 - 10.1007/BF02984618
DO - 10.1007/BF02984618
M3 - Article
C2 - 16097635
AN - SCOPUS:23344435367
SN - 0914-7187
VL - 19
SP - 267
EP - 275
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
IS - 4
ER -