TY - JOUR
T1 - Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses
AU - Ito, Isao
AU - Okada, Daisuke
AU - Sugiyama, Hiroyuki
PY - 1988/7/19
Y1 - 1988/7/19
N2 - The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected controls, suggesting the involvement of G-proteins in the mechanism of LTP in mossy fiber synapses. In contrast, LTP in Schaffer/commissural-CA1 pyramidal synapses was not affected by PTX pretreatment.
AB - The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected controls, suggesting the involvement of G-proteins in the mechanism of LTP in mossy fiber synapses. In contrast, LTP in Schaffer/commissural-CA1 pyramidal synapses was not affected by PTX pretreatment.
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U2 - 10.1016/0304-3940(88)90808-7
DO - 10.1016/0304-3940(88)90808-7
M3 - Article
C2 - 3412640
AN - SCOPUS:0023907869
SN - 0304-3940
VL - 90
SP - 181
EP - 185
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -