Peroxisome homeostasis: Mechanisms of division and selective degradation of peroxisomes in mammals

Masanori Honsho, Shun ichi Yamashita, Yukio Fujiki

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Peroxisome number and quality are maintained by its biogenesis and turnover and are important for the homeostasis of peroxisomes. Peroxisomes are increased in number by division with dynamic morphological changes including elongation, constriction, and fission. In the course of peroxisomal division, peroxisomal morphogenesis is orchestrated by Pex11β, dynamin-like protein 1 (DLP1), and mitochondrial fission factor (Mff). Conversely, peroxisome number is reduced by its degradation. Peroxisomes are mainly degraded by pexophagy, a type of autophagy specific for peroxisomes. Upon pexophagy, an adaptor protein translocates on peroxisomal membrane and connects peroxisomes to autophagic machineries. Molecular mechanisms of pexophagy are well studied in yeast systems where several specific adaptor proteins are identified. Pexophagy in mammals also proceeds in a manner dependent on adaptor proteins. In this review, we address the recent progress in studies on peroxisome morphogenesis and pexophagy. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann.

Original languageEnglish
Pages (from-to)984-991
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Issue number5
Publication statusPublished - May 1 2016

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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