TY - JOUR
T1 - Peroxisome biogenesis disorders
T2 - Identification of a new complementation group distinct from peroxisome-deficient CHO mutants and not complemented by human PEX 13
AU - Shimozawa, Nobuyuki
AU - Suzuki, Yasuyuki
AU - Zhang, Zhongyi
AU - Imamura, Atsushi
AU - Tsukamoto, Toshiro
AU - Osumi, Takashi
AU - Tateishi, Keita
AU - Okumoto, Kanji
AU - Fujiki, Yukio
AU - Orii, Tadao
AU - Barth, Peter G.
AU - Wanders, Ronald J.A.
AU - Kondo, Naomi
N1 - Funding Information:
We thank K. Hori for technical assistance, and Ann B. Moser of KKI and M. Ohara for helpful comments. This study was supported in part by a grant-in-aid for Scienti®c Research (08670870) from the Ministry of Education, Science, Sports and Culture of Japan, by a research grant from the National Center of Neurology and Psychiatry of the Ministry of Health and Welfare of Japan, and by a research grant from ONO Medical Research Foundation.
PY - 1998/2/13
Y1 - 1998/2/13
N2 - Ten complementation groups of generalized peroxisome biogenesis disorders (PBD), (excluding rhizomelic chondrodysplasia punctata) have been identified using complementation analysis. Four of the genes involved have been identified using two different methods of (1) genetic functional complementation of peroxisome deficient CHO cell mutants and (2) homology searches for human dbEST, based on yeast genes involved in peroxisome biogenesis (PEX genes). We report here the first identification of a new complementation group which is genetically different from peroxisome deficient CHO mutants. There were no complementations by the human PEX 13 gene. The nature of the related gene is being investigated.
AB - Ten complementation groups of generalized peroxisome biogenesis disorders (PBD), (excluding rhizomelic chondrodysplasia punctata) have been identified using complementation analysis. Four of the genes involved have been identified using two different methods of (1) genetic functional complementation of peroxisome deficient CHO cell mutants and (2) homology searches for human dbEST, based on yeast genes involved in peroxisome biogenesis (PEX genes). We report here the first identification of a new complementation group which is genetically different from peroxisome deficient CHO mutants. There were no complementations by the human PEX 13 gene. The nature of the related gene is being investigated.
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U2 - 10.1006/bbrc.1997.8067
DO - 10.1006/bbrc.1997.8067
M3 - Article
C2 - 9480815
AN - SCOPUS:0032512540
SN - 0006-291X
VL - 243
SP - 368
EP - 371
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -